HAMAP

Accession	MF_01516
Dates	25-MAY-2004 (Created) 2-DEC-2011 (Last updated, Version 13)

Data class

Protein

Predictors

HAMAP; MF_01516; [distribution of match scores in UniProtKB];[seed alignment for MF_01516]

Names

Malate_dehydrog_1

Identifier

MDH

Protein name

RecName: Full=Malate dehydrogenase; EC=1.1.1.37;

Gene name

mdh

FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity).

CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family.

Pfam	PF02866; Ldh_1_C; 1; PF00056; Ldh_1_N; 1;
TIGRFAMs	TIGR01772; MDH_euk_gproteo; 1;
PROSITE	PS00068; MDH; 1;

Oxidoreductase, Tricarboxylic acid cycle, NAD.

GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

From: MDH_ECOLI (P61889)
Key		From		To		Description		Condition		FTGroup
NP_BIND		7		13		NAD (By similarity)		G-A-[AS]-G-G-I-G
NP_BIND		117		119		NAD (By similarity)		[IV]-T-N
ACT_SITE		177		177		Proton acceptor (By similarity)		H
BINDING		34		34		NAD (By similarity)		D
BINDING		81		81		Substrate (By similarity)		R
BINDING		87		87		Substrate (By similarity)		R
BINDING		94		94		NAD (By similarity)		N
BINDING		119		119		Substrate (By similarity)		N
BINDING		153		153		Substrate (By similarity)		R
BINDING		227		227		NAD (By similarity)		M

Size range:	310-324 amino acids
Related UniRules:	MF_00487 (MDH); MF_00488 (LDH); MF_01517 (MDH)
Template:	P61889 (MDH_ECOLI); Q7X3X5 (MDH_MORS2); P48364 (MDH_MORS5): [Recover all]
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None