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| HAMAP annotation rule MF_01517 |
| Accession | MF_01517 |
| Dates | 27-MAY-2004 (Created) 2-DEC-2011 (Last updated, Version 16) |
| Name | Malate_dehydrog_2 |
| Scope | Bacteria |
| Triggered by |
| Identifier |
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| Protein name |
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| Gene name |
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| FUNCTION | Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity). |
| CATALYTIC ACTIVITY | (S)-malate + NAD(+) = oxaloacetate + NADH. |
| SUBUNIT | Homodimer (By similarity). |
| SIMILARITY | Belongs to the LDH/MDH superfamily. MDH type 2 family. |
GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.
GO:0006099; Biological process: tricarboxylic acid cycle.
| Pfam | PF02866; Ldh_1_C; 1; |
| PF00056; Ldh_1_N; 1; | |
| TIGRFAMs | TIGR01756; LDH_protist; 1; |
| TIGR01757; Malate-DH_plant; 1; | |
| TIGR01759; MalateDH-SF1; 1; | |
| TIGR01758; MDH_euk_cyt; 1; | |
| PROSITE | PS00068; MDH; 1; |
| From: MDH_THETH (P10584) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 11 | 17 | NAD (By similarity) | G-[AG]-x-G-x-[IV]-[GACS] | ||||||||
| NP_BIND | 129 | 131 | NAD (By similarity) | [VT]-G-N | ||||||||
| ACT_SITE | 187 | 187 | Proton acceptor (By similarity) | H | ||||||||
| BINDING | 92 | 92 | Substrate (By similarity) | R | ||||||||
| BINDING | 98 | 98 | Substrate (By similarity) | R | ||||||||
| BINDING | 105 | 105 | NAD (By similarity) | N | ||||||||
| BINDING | 112 | 112 | NAD (By similarity) | Q | ||||||||
| BINDING | 131 | 131 | Substrate (By similarity) | N | ||||||||
| BINDING | 162 | 162 | Substrate (By similarity) | R | ||||||||
| Size range: | 323-335 amino acids |
| Related Rules: | MF_00487 (MDH); MF_00488 (LDH); MF_01516 (MDH) |
| Template: | P10584 (MDH_THETH) |
| Fusion: | None |