HAMAP rule MF_01524
General rule information
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| Accession | MF_01524 |
| Dates | 23-NOV-2004 (Created)
15-DEC-2022 (Last updated, Version 16) |
| Name | CaiC |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P31552 (CAIC_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01524 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CAIC |
| Protein name | RecName: Full=Crotonobetaine/carnitine--CoA ligase; EC=6.2.1.48; |
| Gene name | Name=caiC; |
Comments
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| FUNCTION | Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine. |
| CATALYTIC ACTIVITY | Reaction=(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:28514, ChEBI:CHEBI:16347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:60932, ChEBI:CHEBI:456215; EC=6.2.1.48; |
| CATALYTIC ACTIVITY | Reaction=ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate; Xref=Rhea:RHEA:30079, ChEBI:CHEBI:17237, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:60933, ChEBI:CHEBI:456215; |
| CATALYTIC ACTIVITY | Reaction=4-(trimethylamino)butanoate + ATP + CoA = 4- (trimethylamino)butanoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:55960, ChEBI:CHEBI:16244, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61513, ChEBI:CHEBI:456215; |
| PATHWAY | Amine and polyamine metabolism; carnitine metabolism. |
| SIMILARITY | Belongs to the ATP-dependent AMP-binding enzyme family. |
Keywords
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Gene Ontology
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| GO:0016405; Molecular function:CoA-ligase activity |
Cross-references
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Features
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Additional information
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| Size range | 510-518 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |