HAMAP rule MF_01524

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01524
Accession	MF_01524
Dates	23-NOV-2004 (Created) 3-SEP-2024 (Last updated, Version 18)
Name	CaiC
Scope(s)	Bacteria Enterobacterales
Template(s)	P31552 (CAIC_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01524 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	CAIC
Protein name	RecName: Full=Crotonobetaine/carnitine--CoA ligase; EC=6.2.1.48;
Gene name	Name=caiC;

Comments [?]

FUNCTION	Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
CATALYTIC ACTIVITY	Reaction=(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:28514, ChEBI:CHEBI:16347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:60932, ChEBI:CHEBI:456215; EC=6.2.1.48;
CATALYTIC ACTIVITY	Reaction=crotonobetaine + ATP + CoA = crotonobetainyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:30079, ChEBI:CHEBI:17237, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:60933, ChEBI:CHEBI:456215;
CATALYTIC ACTIVITY	Reaction=4-(trimethylamino)butanoate + ATP + CoA = 4- (trimethylamino)butanoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:55960, ChEBI:CHEBI:16244, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61513, ChEBI:CHEBI:456215;
PATHWAY	Amine and polyamine metabolism; carnitine metabolism.
SIMILARITY	Belongs to the ATP-dependent AMP-binding enzyme family.

Keywords [?]

Gene Ontology [?]

GO:0016405; Molecular function:CoA-ligase activity

GO:0009437; Biological process:carnitine metabolic process

Cross-references [?]

Features [?]

Additional information [?]