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HAMAP annotation rule: MF_01529
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General rule information

Accession MF_01529
Dates 14-FEB-2005 (Created)
7-OCT-2011 (Last updated, Version 23)
Data class Protein
Predictors HAMAP; MF_01529; [distribution of match scores in UniProtKB];[seed alignment for MF_01529]
Names MFS_MdtH


Propagated annotation

Identifier, protein and gene names
Identifier MDTH
Protein name
RecName: Full=Multidrug resistance protein MdtH;
Gene name mdtH
Comments

case <OC:Escherichia>
FUNCTION: Confers resistance to norfloxacin and enoxacin (By similarity).
end case


case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case

SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
Cross-references
Pfam PF07690; MFS_1; 1;
PROSITE PS50850; MFS; 1;
case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
General Transmembrane; -; 10-12; trigger=Yes;
end case

Keywords

case <OC:Escherichia>
Antibiotic resistance.
end case

Cell membrane.

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case

Membrane, Transmembrane, Transport, Transmembrane helix.
Gene Ontology
GO:0005215; Molecular function: transporter activity.
GO:0006810; Biological process: transport.
GO:0005886; Cellular component: plasma membrane.
Features

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
From: MDTH_ECOLI (P69367)
Key     From     To       Description   Condition   FTGroup
TOPO_DOM     Nter     12       Cytoplasmic (Potential)      
TRANSMEM     13     33       Helical; (Potential)      
TOPO_DOM     34     98       Periplasmic (Potential)      
TRANSMEM     99     116       Helical; (Potential)      
TOPO_DOM     117     138       Cytoplasmic (Potential)      
TRANSMEM     139     159       Helical; (Potential)      
TOPO_DOM     160     164       Periplasmic (Potential)      
TRANSMEM     165     185       Helical; (Potential)      
TOPO_DOM     186     213       Cytoplasmic (Potential)      
TRANSMEM     214     234       Helical; (Potential)      
TOPO_DOM     235     243       Periplasmic (Potential)      
TRANSMEM     244     264       Helical; (Potential)      
TOPO_DOM     265     276       Cytoplasmic (Potential)      
TRANSMEM     277     297       Helical; (Potential)      
TOPO_DOM     298     299       Periplasmic (Potential)      
TRANSMEM     300     320       Helical; (Potential)      
TOPO_DOM     321     339       Cytoplasmic (Potential)      
TRANSMEM     340     360       Helical; (Potential)      
TOPO_DOM     361     367       Periplasmic (Potential)      
TRANSMEM     368     388       Helical; (Potential)      
TOPO_DOM     389     Cter       Cytoplasmic (Potential)      
end case



Additional information

Size range: 397-411 amino acids
Related UniRules: None
Template: P69367 (MDTH_ECOLI)
Scope: Bacteria; Gammaproteobacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences