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HAMAP annotation rule: MF_01530
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General rule information

Accession MF_01530
Dates 14-FEB-2005 (Created)
7-OCT-2011 (Last updated, Version 24)
Data class Protein
Predictors HAMAP; MF_01530; [distribution of match scores in UniProtKB];[seed alignment for MF_01530]
Names MFS_MdtL


Propagated annotation

Identifier, protein and gene names
Identifier MDTL
Protein name
RecName: Full=Multidrug resistance protein MdtL;
Gene name mdtL
Comments

case <OC:Escherichia>
FUNCTION: Confers resistance to chloramphenicol (By similarity).
end case


case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case

SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily.
Cross-references
Pfam PF07690; MFS_1; 1;
PROSITE PS50850; MFS; 1;
General Transmembrane; -; 12; trigger=Yes;
Keywords

case <OC:Escherichia>
Antibiotic resistance.
Cell membrane.

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane.
end case

Membrane, Transmembrane, Transport, Transmembrane helix.
Gene Ontology
GO:0005215; Molecular function: transporter activity.
GO:0006810; Biological process: transport.
GO:0005886; Cellular component: plasma membrane.


Additional information

Size range: 390-396 amino acids
Related UniRules: None
Template: P31462 (MDTL_ECOLI)
Scope: Bacteria; Gammaproteobacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences