HAMAP

Accession	MF_01550
Dates	25-NOV-2005 (Created) 2-DEC-2011 (Last updated, Version 9)

Data class

Protein

Predictors

HAMAP; MF_01550; [distribution of match scores in UniProtKB];[seed alignment for MF_01550]

Names

GppA

Identifier

GPPA

Protein name

RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase; EC=3.6.1.40; AltName: Full=Guanosine pentaphosphate phosphohydrolase; AltName: Full=pppGpp-5'-phosphohydrolase;

Gene name

gppA

FUNCTION: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities (By similarity).

CATALYTIC ACTIVITY: Guanosine 5'-triphosphate,3'-diphosphate + H(2)O = guanosine 3',5'-bis(diphosphate) + phosphate.

PATHWAY: Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.

SIMILARITY: Belongs to the gppA/ppx family. GppA subfamily.

Pfam	PF02541; Ppx-GppA; 1;

Hydrolase.

GO:0008894; Molecular function: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity.

Size range:	493-503 amino acids
Related UniRules:	None
Template:	P25552 (GPPA_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None