HAMAP rule MF_01551
General rule information
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Accession | MF_01551 |
Dates | 28-NOV-2005 (Created)
26-JAN-2023 (Last updated, Version 21) |
Name | 23SrRNA_methyltr_M |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0ADR6 (RLMM_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01551 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | RLMM |
Protein name | RecName: Full=Ribosomal RNA large subunit methyltransferase M; EC=2.1.1.186; AltName: Full=23S rRNA (cytidine2498-2'-O)-methyltransferase; AltName: Full=23S rRNA 2'-O-ribose methyltransferase RlmM; |
Gene name | Name=rlmM; |
Comments
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FUNCTION | Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA. |
CATALYTIC ACTIVITY | Reaction=cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O- methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42788, Rhea:RHEA-COMP:10244, Rhea:RHEA-COMP:10245, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.186; |
SUBUNIT | Monomer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. |
Keywords
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Gene Ontology
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GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity |
GO:0006364; Biological process:rRNA processing |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF01728; FtsJ; 1; |
PIRSF | PIRSF028774; UCP028774; 1; |
Features
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From: RLMM_ECOLI (P0ADR6) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 306 | 306 | /note="Proton acceptor" | K | ||||||||
BINDING | 221 | 224 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[CSA]-P-G-G | ||||||||
BINDING | 188 | 188 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
S | ||||||||
BINDING | 240 | 240 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
BINDING | 260 | 260 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D | ||||||||
BINDING | 277 | 277 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D |
Additional information
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Size range | 339-389 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |