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HAMAP rule MF_01551

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General rule information [?]

Accession MF_01551
Dates 28-NOV-2005 (Created)
26-JAN-2023 (Last updated, Version 21)
Name 23SrRNA_methyltr_M
Scope(s) Bacteria
Pseudomonadota
Template(s) P0ADR6 (RLMM_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01551 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RLMM
Protein name RecName: Full=Ribosomal RNA large subunit methyltransferase M;
                 EC=2.1.1.186;
AltName: Full=23S rRNA (cytidine2498-2'-O)-methyltransferase;
AltName: Full=23S rRNA 2'-O-ribose methyltransferase RlmM;
Gene name Name=rlmM;

Comments [?]

FUNCTIONCatalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
CATALYTIC ACTIVITY Reaction=cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O- methylcytidine(2498) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42788, Rhea:RHEA-COMP:10244, Rhea:RHEA-COMP:10245, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.186;
SUBUNITMonomer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity
GO:0006364; Biological process:rRNA processing
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01728; FtsJ; 1;
PIRSF PIRSF028774; UCP028774; 1;

Features [?]

From: RLMM_ECOLI (P0ADR6)
Key From To Description Tag Condition FTGroup
ACT_SITE 306 306 /note="Proton acceptor" K
BINDING 221 224 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
[CSA]-P-G-G
BINDING 188 188 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
S
BINDING 240 240 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D
BINDING 260 260 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D
BINDING 277 277 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"
D

Additional information [?]

Size range 339-389 amino acids
Related rules None
Fusion Nter: None Cter: None



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