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HAMAP rule MF_01558

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General rule information [?]

Accession MF_01558
Dates 12-DEC-2005 (Created)
1-JUN-2023 (Last updated, Version 21)
Name Cyt_deam
Scope(s) Bacteria
Gammaproteobacteria
Template(s) P0ABF6 (CDD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01558 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CDD
Protein name RecName: Full=Cytidine deaminase;
                 EC=3.5.4.5;
AltName: Full=Cytidine aminohydrolase;
                 Short=CDA;
Gene name Name=cdd;

Comments [?]

FUNCTIONThis enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
CATALYTIC ACTIVITY Reaction=cytidine + H(+) + H2O = NH4(+) + uridine; Xref=Rhea:RHEA:16069, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:17562, ChEBI:CHEBI:28938; EC=3.5.4.5;
CATALYTIC ACTIVITY Reaction=2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+); Xref=Rhea:RHEA:13433, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15698, ChEBI:CHEBI:16450, ChEBI:CHEBI:28938; EC=3.5.4.5;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion.;
end case
SUBUNITHomodimer.
SIMILARITYBelongs to the cytidine and deoxycytidylate deaminase family.

Keywords [?]

Hydrolase
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0004126; Molecular function:cytidine deaminase activity
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Pfam PF00383; dCMP_cyt_deam_1; 1;
Pfam PF08211; dCMP_cyt_deam_2; 1;
NCBIfam TIGR01355; Cyt_deam_dimer; 1;
PROSITE PS00903; CYT_DCMP_DEAMINASES_1; 1;
PROSITE PS51747; CYT_DCMP_DEAMINASES_2; 2;

Features [?]

From: CDD_ECOLI (P0ABF6)
Key From To Description Tag Condition FTGroup
BINDING 89 91 /ligand="substrate" N-x-E
ACT_SITE 104 104 /note="Proton donor" E
BINDING 102 102 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
H 1
BINDING 129 129 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
C 1
BINDING 132 132 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"
C 1

Additional information [?]

Size range 292-309 amino acids
Related rules None
Fusion Nter: None Cter: None



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