HAMAP

Accession	MF_01570
Dates	21-AUG-2006 (Created) 2-DEC-2011 (Last updated, Version 9)

Data class

Protein

Predictors

HAMAP; MF_01570; [distribution of match scores in UniProtKB];[seed alignment for MF_01570]

Names

Pro_tRNA_synth_type2

Identifier

SYP

Protein name

RecName: Full=Proline--tRNA ligase; EC=6.1.1.15; AltName: Full=Prolyl-tRNA synthetase; Short=ProRS;

Gene name

proS

FUNCTION: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity).

CATALYTIC ACTIVITY: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily.

PROSITE	PS50862; AA_TRNA_LIGASE_II; 1;
Pfam	PF03129; HGTP_anticodon; 1; PF00587; tRNA-synt_2b; 1;
PRINTS	PR01046; TRNASYNTHPRO; 1;
TIGRFAMs	TIGR00409; ProS_fam_II; 1;

Cytoplasm, Aminoacyl-tRNA synthetase, ATP-binding, Ligase, Nucleotide-binding, Protein biosynthesis.

GO:0005524; Molecular function: ATP binding.
GO:0004827; Molecular function: proline-tRNA ligase activity.
GO:0006433; Biological process: prolyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Size range:	422-464 amino acids
Related UniRules:	MF_01569 (SYP); MF_01571 (SYP)
Template:	Q6N5P6 (SYP_RHOPA)
Scope:	Bacteria; Alphaproteobacteria Bacteria; Epsilonproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None