HAMAP

Accession	MF_01573
Dates	31-OCT-2006 (Created) 1-DEC-2011 (Last updated, Version 8)

Data class

Protein

Predictors

HAMAP; MF_01573; [distribution of match scores in UniProtKB];[seed alignment for MF_01573]

Names

Pyl_tRNA_synth

Identifier

PYLS

Protein name

RecName: Full=Pyrrolysine--tRNA ligase; EC=6.1.1.26; AltName: Full=Pyrrolysyl-tRNA synthetase; Short=PylRS;

Gene name

pylS

FUNCTION: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG (By similarity).

CATALYTIC ACTIVITY: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.

PROSITE	PS50862; AA_TRNA_LIGASE_II; 1;
Pfam	PF00587; tRNA-synt_2b; 1;
TIGRFAMs	TIGR02367; PylS; 1;

Cytoplasm, Aminoacyl-tRNA synthetase, ATP-binding, Ligase, Nucleotide-binding, Protein biosynthesis.

GO:0004812; Molecular function: aminoacyl-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006418; Biological process: tRNA aminoacylation for protein translation.
GO:0005737; Cellular component: cytoplasm.

Size range:	416-478 amino acids
Related UniRules:	None
Template:	Q6WRH6 (PYLS_METBA); Q46E77 (PYLS_METBF): [Recover all]
Scope:	Archaea; Methanosarcinales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None