HAMAP

Accession	MF_01578
Dates	23-FEB-2007 (Created) 12-SEP-2011 (Last updated, Version 12)

Data class

Protein

Predictors

HAMAP; MF_01578; [distribution of match scores in UniProtKB];[seed alignment for MF_01578]

Names

Shikimate_DH_YdiB

Identifier

YDIB

Protein name

RecName: Full=Quinate/shikimate dehydrogenase; EC=1.1.1.282; AltName: Full=NAD-dependent shikimate 5-dehydrogenase 2;

Gene name

ydiB

CATALYTIC ACTIVITY: L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H.

CATALYTIC ACTIVITY: Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H.

PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the shikimate dehydrogenase family.

Pfam	PF01488; Shikimate_DH; 1; PF08501; Shikimate_dh_N; 1;

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, NAD, Oxidoreductase.

GO:0030266; Molecular function: quinate 3-dehydrogenase (NAD+) activity.
GO:0004764; Molecular function: shikimate 3-dehydrogenase (NADP+) activity.
GO:0009073; Biological process: aromatic amino acid family biosynthetic process.

From: YDIB_ECOLI (P0A6D5)
Key		From		To		Description		Condition		FTGroup
NP_BIND		131		135		NAD (By similarity)		G-A-G-G-A
NP_BIND		155		158		NAD (By similarity)		N-R-[RK]-D
NP_BIND		255		259		NAD (By similarity)		G-Y-G-M-L
ACT_SITE		71		71		Proton acceptor (Potential)		K
BINDING		107		107		Substrate (By similarity)		D
BINDING		205		205		NAD; via amide nitrogen (By similarity)		K
BINDING		235		235		NAD (By similarity)		N

Size range:	288-297 amino acids
Related UniRules:	MF_00222 (AROE)
Template:	P0A6D5 (YDIB_ECOLI)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Divergent N-terminus in SHIDS and SHIF8; sequences not included in alignment and not taken into account in size range