HAMAP

Accession	MF_01587
Dates	15-NOV-2007 (Created) 2-DEC-2011 (Last updated, Version 7)

Data class

Protein

Predictors

HAMAP; MF_01587; [distribution of match scores in UniProtKB];[seed alignment for MF_01587]

Names

DNA_ligase_B

Identifier

LIGB

Protein name

RecName: Full=DNA ligase B; EC=6.5.1.2; AltName: Full=Polydeoxyribonucleotide synthase [NAD+] B;

Gene name

ligB

FUNCTION: Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity).

CATALYTIC ACTIVITY: NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + nicotinamide nucleotide + (deoxyribonucleotide)(n+m).

SIMILARITY: Belongs to the NAD-dependent DNA ligase family. LigB subfamily.

PROSITE	PS01055; DNA_LIGASE_N1; 1; PS01056; DNA_LIGASE_N2; 1;
Pfam	PF01653; DNA_ligase_aden; 1; PF03120; DNA_ligase_OB; 1;

DNA damage, DNA repair, DNA replication, Ligase, NAD.

GO:0003911; Molecular function: DNA ligase (NAD+) activity.
GO:0006259; Biological process: DNA metabolic process.

From: LIGB_ECOLI (P25772)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		124		124		N6-AMP-lysine intermediate (By similarity)		K

Size range:	554-629 amino acids
Related UniRules:	MF_01588 (DNLJ)
Template:	P25772 (LIGB_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None