HAMAP rule MF_01589
General rule information
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| Accession | MF_01589 |
| Dates | 29-NOV-2007 (Created)
1-JUN-2023 (Last updated, Version 20) |
| Name | Cx_SAM_synthase |
| Scope(s) |
Bacteria |
| Template(s) | P76290 (CMOA_ECOLI); Q7CQC4 (CMOA_SALTY); P43985 (CMOA_HAEIN); [ Recover all ] |
| Triggered by |
HAMAP; MF_01589 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CMOA |
| Protein name | RecName: Full=Carboxy-S-adenosyl-L-methionine synthase; Short=Cx-SAM synthase; EC=2.1.3.-; |
| Gene name | Name=cmoA; |
Comments
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| FUNCTION | Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM). |
| CATALYTIC ACTIVITY | Reaction=prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O; Xref=Rhea:RHEA:51692, ChEBI:CHEBI:15377, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934, ChEBI:CHEBI:59789, ChEBI:CHEBI:134278; |
| case <OC:Pseudomonadota> | |
| SUBUNIT | Homodimer. |
| end case | |
| SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family. |
Keywords
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Gene Ontology
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| GO:0016743; Molecular function:carboxyl- or carbamoyltransferase activity |
| GO:1904047; Molecular function:S-adenosyl-L-methionine binding |
Cross-references
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| Pfam | PF08241; Methyltransf_11; 1; |
| Pfam | PF08242; Methyltransf_12; 1; |
| PIRSF | PIRSF006325; MeTrfase_bac; 1; |
| NCBIfam | TIGR00740; TIGR00740; 1; |
Features
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| From: CMOA_ECOLI (P76290) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 64 | 66 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G-x-S | ||||||||
| BINDING | 89 | 90 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D-N | ||||||||
| BINDING | 117 | 118 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
D-[ILV] | ||||||||
| BINDING | 39 | 39 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
Y | ||||||||
| BINDING | 132 | 132 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
N | ||||||||
| BINDING | 199 | 199 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
R | ||||||||
Additional information
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| Size range | 228-274 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |