HAMAP

Accession	MF_01594
Dates	1-FEB-2008 (Created) 2-DEC-2011 (Last updated, Version 12)

Data class

Protein

Predictors

HAMAP; MF_01594; [distribution of match scores in UniProtKB];[seed alignment for MF_01594]

Names

Rhomboid_GlpG

Identifier

GLPG

Protein name

RecName: Full=Rhomboid protease glpG; EC=3.4.21.105; AltName: Full=Intramembrane serine protease;

Gene name

glpG

FUNCTION: Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity).

CATALYTIC ACTIVITY: Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the peptidase S54 family.

Pfam	PF01694; Rhomboid; 1;
General	Transmembrane; -; 6; trigger=Yes;

Cell membrane, Hydrolase.

Cell inner membrane.

Membrane, Protease, Serine protease, Transmembrane, Transmembrane helix.

GO:0004252; Molecular function: serine-type endopeptidase activity.
GO:0006508; Biological process: proteolysis.
GO:0005886; Cellular component: plasma membrane.

From: GLPG_ECOLI (P09391)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		201		201		Nucleophile (By similarity)		S
ACT_SITE		254		254		By similarity		H

Size range:	276-282 amino acids
Related UniRules:	None
Template:	P09391 (GLPG_ECOLI)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Active sites are not conserved in CROS8, suggesting that it has no peptidase activity.