HAMAP

Accession	MF_01595
Dates	19-MAR-2008 (Created) 2-DEC-2011 (Last updated, Version 8)

Data class

Protein

Predictors

HAMAP; MF_01595; [distribution of match scores in UniProtKB];[seed alignment for MF_01595]

Names

PNPase

Identifier

PNP

Protein name

RecName: Full=Polyribonucleotide nucleotidyltransferase; EC=2.7.7.8; AltName: Full=Polynucleotide phosphorylase; Short=PNPase;

Gene name

pnp

FUNCTION: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity).

CATALYTIC ACTIVITY: RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.

SUBUNIT: Homotrimer. Organized into a structure (processome or RNA degradosome) containing a number of RNA-processing enzymes (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the polyribonucleotide nucleotidyltransferase family.

PROSITE	PS50084; KH_TYPE_1; 1; trigger=PRU00117; PS50126; S1; 1; trigger=PRU00180;
Pfam	PF00013; KH_1; 1; PF03726; PNPase; 1; PF01138; RNase_PH; 2; PF03725; RNase_PH_C; 2; PF00575; S1; 1;
PIRSF	PIRSF005499; PNPase; 1;
TIGRFAMs	TIGR03591; Polynuc_phos; 1; TIGR02696; pppGpp_PNP; 1;

Cytoplasm, Nucleotidyltransferase, RNA-binding, Transferase.

GO:0004654; Molecular function: polyribonucleotide nucleotidyltransferase activity.
GO:0006402; Biological process: mRNA catabolic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	686-914 amino acids
Related UniRules:	None
Template:	P05055 (PNP_ECOLI); Q8ZLT3 (PNP_SALTY); P50849 (PNP_BACSU); Q53597 (PNP_STRAT): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in ALKMQ
Plasmid encoded:	None