HAMAP

Accession	MF_01603
Dates	30-SEP-2004 (Created) 7-OCT-2011 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_01603; [distribution of match scores in UniProtKB];[seed alignment for MF_01603]

Names

HldE

Identifier

HLDE

Protein name

RecName: Full=Bifunctional protein hldE; RecName: Full=D-beta-D-heptose 7-phosphate kinase; EC=2.7.1.-; AltName: Full=D-beta-D-heptose 7-phosphotransferase; RecName: Full=D-beta-D-heptose 1-phosphate adenosyltransferase; EC=2.7.7.-;

Gene name

hldE

FUNCTION: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to form D,D-heptose-1,7-bisphosphate (By similarity).

FUNCTION: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity).

CATALYTIC ACTIVITY: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate.

CATALYTIC ACTIVITY: ATP + D-glycero-beta-D-manno-heptose 1-phosphate = diphosphate + ADP-D-glycero-beta-D-manno-heptose.

PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.

PATHWAY: Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: In the N-terminal section; belongs to the carbohydrate kinase pfkB family.

SIMILARITY: In the C-terminal section; belongs to the cytidylyltransferase family.

Pfam	PF01467; CTP_transf_2; 1; PF00294; PfkB; 1;
TIGRFAMs	TIGR00125; Cyt_tran_rel; 1; TIGR02198; RfaE_dom_I; 1; TIGR02199; RfaE_dom_II; 1;
PROSITE	PS00583; PFKB_KINASES_1; 1; PS00584; PFKB_KINASES_2; 1;

Acetylation.

ATP-binding, Carbohydrate metabolism, Kinase, Multifunctional enzyme, Nucleotide-binding, Nucleotidyltransferase, Transferase.

GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0019200; Molecular function: carbohydrate kinase activity.
GO:0005975; Biological process: carbohydrate metabolic process.

From: HLDE_ECOLI (P76658)
Key		From		To		Description		Condition		FTGroup
NP_BIND		195		198		ATP (Potential)		N-x-x-E
REGION		Nter		318		Ribokinase
REGION		344		Cter		Cytidylyltransferase
ACT_SITE		264		264		Potential		D

Key		From		To		Description		Condition		FTGroup
MOD_RES		179		179		N6-acetyllysine (By similarity)		K

Size range:	458-496 amino acids
Related UniRules:	None
Template:	P76658 (HLDE_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None