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HAMAP rule MF_01603

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General rule information [?]

Accession MF_01603
Dates 30-SEP-2004 (Created)
1-JUN-2023 (Last updated, Version 27)
Name HldE
Scope(s) Bacteria
Template(s) P76658 (HLDE_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01603 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HLDE
Protein name RecName: Full=Bifunctional protein HldE;
                 Includes:
RecName: Full=D-beta-D-heptose 7-phosphate kinase;
                 EC=2.7.1.167;
AltName: Full=D-beta-D-heptose 7-phosphotransferase;
AltName: Full=D-glycero-beta-D-manno-heptose-7-phosphate kinase;
                 Includes:
RecName: Full=D-beta-D-heptose 1-phosphate adenylyltransferase;
                 EC=2.7.7.70;
AltName: Full=D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase;
Gene name Name=hldE;

Comments [?]

FUNCTIONCatalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate.
FUNCTIONCatalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
CATALYTIC ACTIVITY Reaction=ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D- glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+); Xref=Rhea:RHEA:27473, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:60204, ChEBI:CHEBI:60208, ChEBI:CHEBI:456216; EC=2.7.1.167;
CATALYTIC ACTIVITY Reaction=ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP- D-glycero-beta-D-manno-heptose + diphosphate; Xref=Rhea:RHEA:27465, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:59967, ChEBI:CHEBI:61593; EC=2.7.7.70;
PATHWAYNucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno- heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D- glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
PATHWAYNucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno- heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D- glycero-beta-D-manno-heptose 7-phosphate: step 3/4.
SUBUNITHomodimer.
SIMILARITYIn the N-terminal section; belongs to the carbohydrate kinase PfkB family.
SIMILARITYIn the C-terminal section; belongs to the cytidylyltransferase family.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0033785; Molecular function:heptose 7-phosphate kinase activity
GO:0033786; Molecular function:heptose-1-phosphate adenylyltransferase activity
GO:0005975; Biological process:carbohydrate metabolic process

Cross-references [?]

Pfam PF01467; CTP_transf_2; 1;
Pfam PF00294; PfkB; 1;
NCBIfam TIGR00125; Cyt_tran_rel; 1;
NCBIfam TIGR02198; RfaE_dom_I; 1;
NCBIfam TIGR02199; RfaE_dom_II; 1;
PROSITE PS00583; PFKB_KINASES_1; 1;
PROSITE PS00584; PFKB_KINASES_2; 1;

Features [?]

From: HLDE_ECOLI (P76658)
Key From To Description Tag Condition FTGroup
BINDING 195 198 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
N-x-x-E
REGION Nter 318 /note="Ribokinase"
REGION 344 Cter /note="Cytidylyltransferase"
ACT_SITE 264 264 D
case <OC:Escherichia> or <OC:Shigella>
MOD_RES 179 179 /note="N6-acetyllysine" K
end case

Additional information [?]

Size range 458-496 amino acids
Related rules None
Fusion Nter: None Cter: None



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