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HAMAP rule MF_01610

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General rule information [?]

Accession MF_01610
Dates 12-APR-2005 (Created)
1-JUN-2023 (Last updated, Version 15)
Name MfnA_decarbox
Scope(s) Archaea
Template(s) Q60358 (MFNA_METJA); Q5JJ82 (MFNA_THEKO); O58679 (MFNA_PYRHO); [ Recover all ]
Triggered by HAMAP; MF_01610 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MFNA
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Protein name RecName: Full=Probable L-tyrosine/L-aspartate decarboxylase;
                 Short=TDC/ADC;
                 EC=4.1.1.25;
                 EC=4.1.1.11;
else
Protein name RecName: Full=Probable L-aspartate decarboxylase;
                 Short=ADC;
                 EC=4.1.1.11;
end case
Gene name Name=mfnA;

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
FUNCTIONCatalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
CATALYTIC ACTIVITY Reaction=H(+) + L-tyrosine = CO2 + tyramine; Xref=Rhea:RHEA:14345, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:58315, ChEBI:CHEBI:327995; EC=4.1.1.25;
CATALYTIC ACTIVITY Reaction=H(+) + L-aspartate = beta-alanine + CO2; Xref=Rhea:RHEA:19497, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991, ChEBI:CHEBI:57966; EC=4.1.1.11;
else
FUNCTIONCatalyzes the decarboxylation of L-aspartate to produce beta- alanine.
CATALYTIC ACTIVITY Reaction=H(+) + L-aspartate = beta-alanine + CO2; Xref=Rhea:RHEA:19497, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991, ChEBI:CHEBI:57966; EC=4.1.1.11;
end case
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
PATHWAYCofactor biosynthesis; methanofuran biosynthesis.
end case
PATHWAYCofactor biosynthesis; coenzyme A biosynthesis.
SIMILARITYBelongs to the group II decarboxylase family. MfnA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0030170; Molecular function:pyridoxal phosphate binding
GO:0004068; Molecular function:aspartate 1-decarboxylase activity
GO:0015937; Biological process:coenzyme A biosynthetic process
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0004837; Molecular function:tyrosine decarboxylase activity
GO:2001120; Biological process:methanofuran biosynthetic process
end case

Cross-references [?]

Pfam PF00282; Pyridoxal_deC; 1;
PROSITE PS00392; DDC_GAD_HDC_YDC; 1;
NCBIfam TIGR03812; tyr_de_CO2_Arch; 1;

Features [?]

From: MFNA_METJA (Q60358)
Key From To Description Tag Condition FTGroup
MOD_RES 245 245 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 325-410 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments In methanogens, the essential role of MfnA is to generate tyramine for methanofuran biosynthesis, but it can also supply the small amount of beta-alanine needed for coenzyme A production (see PubMed:24891443).



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