HAMAP rule MF_01618
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_01618 |
| Accession | MF_01618 |
| Dates | 11-NOV-2005 (Created)
3-SEP-2024 (Last updated, Version 22) |
| Name | FadI |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P76503 (FADI_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01618 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | FADI |
| Protein name | RecName: Full=3-ketoacyl-CoA thiolase; EC=2.3.1.16; AltName: Full=ACSs; AltName: Full=Acetyl-CoA acyltransferase; AltName: Full=Acyl-CoA ligase; AltName: Full=Beta-ketothiolase; AltName: Full=Fatty acid oxidation complex subunit beta; |
| Gene name | Name=fadI; |
Comments
[?]
| FUNCTION | Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. |
| CATALYTIC ACTIVITY | Reaction=an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA; Xref=Rhea:RHEA:21564, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58342, ChEBI:CHEBI:90726; EC=2.3.1.16; |
| PATHWAY | Lipid metabolism; fatty acid beta-oxidation. |
| SUBUNIT | Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI). |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the thiolase-like superfamily. Thiolase family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0003988; Molecular function:acetyl-CoA C-acyltransferase activity |
| GO:0006635; Biological process:fatty acid beta-oxidation |
| GO:0016042; Biological process:lipid catabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
| PROSITE | PS00098; THIOLASE_1; 1; |
| PROSITE | PS00737; THIOLASE_2; 1; |
| PROSITE | PS00099; THIOLASE_3; 1; |
| Pfam | PF02803; Thiolase_C; 1; |
| Pfam | PF00108; Thiolase_N; 1; |
| NCBIfam | TIGR01930; AcCoA-C-Actrans; 1; |
| NCBIfam | TIGR02446; FadI; 1; |
Features
[?]
| From: FADI_ECOLI (P76503) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 99 | 99 | /note="Acyl-thioester intermediate" | C | ||||||||
| ACT_SITE | 392 | 392 | /note="Proton acceptor" | H | ||||||||
| ACT_SITE | 422 | 422 | /note="Proton acceptor" | C | ||||||||
Additional information
[?]
| Size range | 435-442 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |