HAMAP

Accession	MF_01619
Dates	16-NOV-2005 (Created) 22-DEC-2010 (Last updated, Version 11)

Data class

Protein

Predictors

HAMAP; MF_01619; [distribution of match scores in UniProtKB];[seed alignment for MF_01619]

Names

NAD_malic_enz

Identifier

MAO1

Protein name

RecName: Full=NAD-dependent malic enzyme; Short=NAD-ME; EC=1.1.1.38;

Gene name

maeA

CATALYTIC ACTIVITY: (S)-malate + NAD(+) = pyruvate + CO(2) + NADH.

COFACTOR: Divalent metal cations. Prefers magnesium or manganese (By similarity).

SUBUNIT: Homotetramer (By similarity).

SIMILARITY: Belongs to the malic enzymes family.

PROSITE	PS00331; MALIC_ENZYMES; 1;
Pfam	PF00390; malic; 1; PF03949; Malic_M; 1;
PRINTS	PR00072; MALOXRDTASE; 1;

Metal-binding, NAD, Oxidoreductase.

GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity.

From: MAO1_ECOLI (P26616)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		104		104		Proton donor (By similarity)		Y
ACT_SITE		175		175		Proton acceptor (By similarity)		K
METAL		246		246		Divalent metal cation (By similarity)		E
METAL		247		247		Divalent metal cation (By similarity)		D
METAL		270		270		Divalent metal cation (By similarity)		D
BINDING		157		157		NAD (By similarity)		R
BINDING		270		270		NAD (By similarity)		D
BINDING		418		418		NAD (By similarity)		N
SITE		270		270		Important for activity (By similarity)

Size range:	528-591 amino acids
Related UniRules:	None
Template:	P26616 (MAO1_ECOLI)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in PHOPR, VIBVY
Plasmid encoded:	None