HAMAP

Accession	MF_01620
Dates	18-NOV-2005 (Created) 7-OCT-2011 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_01620; [distribution of match scores in UniProtKB];[seed alignment for MF_01620]

Names

FadA

Identifier

FADA

Protein name

RecName: Full=3-ketoacyl-CoA thiolase; EC=2.3.1.16; AltName: Full=Acetyl-CoA acyltransferase; AltName: Full=Beta-ketothiolase; AltName: Full=Fatty acid oxidation complex subunit beta;

Gene name

fadA

FUNCTION: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed (By similarity).

CATALYTIC ACTIVITY: Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

PATHWAY: Lipid metabolism; fatty acid beta-oxidation.

SUBUNIT: Heterotetramer of two alpha chains (fadB) and two beta chains (fadA) (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the thiolase family.

PROSITE	PS00098; THIOLASE_1; 1; PS00737; THIOLASE_2; 1; PS00099; THIOLASE_3; 1;
Pfam	PF02803; Thiolase_C; 1; PF00108; Thiolase_N; 1;
TIGRFAMs	TIGR01930; AcCoA-C-Actrans; 1; TIGR02445; FadA; 1;

Cytoplasm, Acyltransferase, Fatty acid metabolism, Lipid degradation, Lipid metabolism, Transferase.

GO:0003988; Molecular function: acetyl-CoA C-acyltransferase activity.
GO:0006631; Biological process: fatty acid metabolic process.
GO:0016042; Biological process: lipid catabolic process.
GO:0005737; Cellular component: cytoplasm.

From: FADA_ECOLI (P21151)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		91		91		Acyl-thioester intermediate (By similarity)		C
ACT_SITE		343		343		Proton acceptor (By similarity)		H
ACT_SITE		373		373		Proton acceptor (By similarity)		C

Size range:	386-392 amino acids
Related UniRules:	None
Template:	P21151 (FADA_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None