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HAMAP annotation rule: MF_01624
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General rule information

Accession MF_01624
Dates 7-DEC-2005 (Created)
7-OCT-2011 (Last updated, Version 14)
Data class Protein
Predictors HAMAP; MF_01624; [distribution of match scores in UniProtKB];[seed alignment for MF_01624]
Names Arsenate_reduct


Propagated annotation

Identifier, protein and gene names
Identifier ARSC
Protein name
RecName: Full=Protein ArsC;
AltName: Full=Arsenate reductase;
EC=1.20.4.-;
AltName: Full=Arsenical pump modifier;
AltName: Full=Low molecular weight protein-tyrosine-phosphatase;
EC=3.1.3.48;
Gene name arsC
Comments
FUNCTION: Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances (By similarity).
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H(2)O.
SUBUNIT: Monomer (By similarity).
SIMILARITY: Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.
Cross-references
Pfam PF01451; LMWPc; 1;
TIGRFAMs TIGR02691; ArsC_pI258_fam; 1;
Keywords
Arsenical resistance.

case <FT:4> or <FT:5>
Disulfide bond.
end case

Hydrolase, Oxidoreductase, Redox-active center.
Gene Ontology
GO:0004725; Molecular function: protein tyrosine phosphatase activity.
GO:0030612; Molecular function: arsenate reductase (thioredoxin) activity.
Features
From: ARSC_STAAU (P0A006)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     10     10       Nucleophile; for reductase activity and phosphatase activity (By similarity)   C  
ACT_SITE     82     82       Nucleophile; for reductase activity (By similarity)   C  
ACT_SITE     89     89       Nucleophile; for reductase activity (By similarity)   C  
DISULFID     10     82       Redox-active; alternate (By similarity)   C-x*-C  
DISULFID     82     89       Redox-active; alternate (By similarity)   C-x*-C  


Additional information

Size range: 130-144 amino acids
Related UniRules: None
Template: P0A006 (ARSC_STAAU)
Scope: Bacteria; Firmicutes
Fusion: Nter: None; Cter: None
Duplicate: in BACC1, STAEQ, STAHJ, STAS1
Plasmid encoded: in BACC1, STAAN, STAAU, STAS1, STAXY

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UniProtKB rule member sequences