HAMAP annotation rule MF_01628
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Accession MF_01628
Dates 14-DEC-2005 (Created)
6-JAN-2012 (Last updated, Version 11)
Name Thymid_phosp
Scope Bacteria; Proteobacteria
Triggered by



Identifier
TYPH
Protein name
RecName: Full=Thymidine phosphorylase;
EC=2.4.2.4;
AltName: Full=TdRPase;
Gene name
deoA


FUNCTION The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).
CATALYTIC ACTIVITY Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
PATHWAY Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine; step 1/2.
SUBUNIT Homodimer (By similarity).
SIMILARITY Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.


Glycosyltransferase
Transferase


GO:0009032; Molecular function: thymidine phosphorylase activity.
GO:0046104; Biological process: thymidine metabolic process.


PROSITE PS00647; THYMID_PHOSPHORYLASE; 1;
Pfam PF02885; Glycos_trans_3N; 1;
PF00591; Glycos_transf_3; 1;


Size range: 438-448 amino acids
Related Rules: None
Template: P07650 (TYPH_ECOLI)
Fusion: None


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