Annotation rule MF_01629
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General rule information [?]

Accession MF_01629
Dates 14-DEC-2005 (Created)
20-MAR-2014 (Last updated, Version 17)
Name PdxH
Scope Bacteria; Actinobacteria
Bacteria; Bacteroidetes
Bacteria; Cyanobacteria
Bacteria; Deinococcus-Thermus
Bacteria; Planctomycetes
Bacteria; Proteobacteria
Bacteria; Spirochaetes
Templates P0AFI7 (PDXH_ECOLI); P9WIJ1 (PDXH_MYCTU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PDXH
Protein name
RecName: Full=Pyridoxine/pyridoxamine 5'-phosphate oxidase;
EC=1.4.3.5;
AltName: Full=PNP/PMP oxidase;
Short=PNPOx;
AltName: Full=Pyridoxal 5'-phosphate synthase;
Gene name
pdxH

Comments [?]

Function Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity).
Catalytic activity Pyridoxamine 5'-phosphate + H(2)O + O(2) = pyridoxal 5'-phosphate + NH(3) + H(2)O(2).
Pyridoxine 5'-phosphate + O(2) = pyridoxal 5'-phosphate + H(2)O(2).
Cofactor Binds 1 FMN per subunit (By similarity).
Pathway Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; step 1/1.
Cofactor biosynthesis; B6 vitamer interconversion; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate; step 1/1.
Subunit Homodimer (By similarity).
Similarity Belongs to the pyridoxamine 5'-phosphate oxidase family.

Keywords [?]


Gene Ontology [?]

GO:0004733; Molecular function: pyridoxamine-phosphate oxidase activity.
GO:0010181; Molecular function: FMN binding.
GO:0042816; Biological process: vitamin B6 metabolic process.

Cross-references [?]

PROSITE PS01064; PYRIDOX_OXIDASE; 1;
Pfam PF01243; Pyridox_oxidase; 1;
TIGRFAMs TIGR00558; PdxH; 1;

Features [?]

From: PDXH_ECOLI (P0AFI7)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     82     83       FMN (By similarity)     [YF]-[TS]  
NP_BIND     146     147       FMN (By similarity)     Q-S  
REGION (Optional)     14     17       Substrate binding (By similarity)     R-x-x-Y  
REGION     197     199       Substrate binding (By similarity)     R-x-[HN]  
BINDING     67     67       FMN (By similarity)     R  
BINDING     70     70       FMN; via amide nitrogen (By similarity)     L  
BINDING     72     72       Substrate (By similarity)     [KR]  
BINDING     89     89       FMN (By similarity)     K  
BINDING     129     129       Substrate (By similarity)     Y  
BINDING     133     133       Substrate (By similarity)     R  
BINDING (Optional)     137     137       Substrate (By similarity)     S  

Additional information [?]

Size range 192-267 amino acids
Related rules None
Fusion None