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HAMAP rule MF_01635

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General rule information [?]

Accession MF_01635
Dates 14-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 25)
Name UbiA
Scope(s) Bacteria
Cyanobacteriota
Pseudomonadota
Template(s) P0AGK1 (UBIA_ECOLI); Q55500 (PLQA_SYNY3); [ Recover all ]
Triggered by
case c? <OC:Bacteria>
HAMAP; MF_01635 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Pseudomonadota>
Identifier UBIA
Protein name RecName: Full=4-hydroxybenzoate octaprenyltransferase;
                 EC=2.5.1.39;
AltName: Full=4-HB polyprenyltransferase;
Gene name Name=ubiA;
else case <OC:Cyanobacteriota>
Identifier PLQA
Protein name RecName: Full=4-hydroxybenzoate solanesyltransferase;
                 EC=2.5.1.39;
AltName: Full=4-HB polyprenyltransferase;
Gene name Name=plqA;
end case

Comments [?]

case <OC:Pseudomonadota>
FUNCTIONCatalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
CATALYTIC ACTIVITY Reaction=4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4- hydroxy-3-all-trans-octaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:27782, ChEBI:CHEBI:1617, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:57711; EC=2.5.1.39;
PATHWAYCofactor biosynthesis; ubiquinone biosynthesis.
else case <OC:Cyanobacteriota>
FUNCTIONCatalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate.
CATALYTIC ACTIVITY Reaction=4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4- hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:17709, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58391, ChEBI:CHEBI:84502; EC=2.5.1.39;
end case
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the UbiA prenyltransferase family.

Keywords [?]


Gene Ontology [?]

case <OCellular component:Pseudomonadota>
GO:0008412; Molecular function:4-hydroxybenzoate octaprenyltransferase activity
GO:0006744; Biological process:ubiquinone biosynthetic process
else case <OCellular component:Cyanobacteriota>
GO:0004659; Molecular function:prenyltransferase activity
GO:0010236; Biological process:plastoquinone biosynthetic process
end case
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

PROSITE PS00943; UBIA; 1;
Pfam PF01040; UbiA; 1;
PRINTS PR01415; ANKYRIN; 1;
NCBIfam TIGR01474; UbiA_proteo; 1;
General Transmembrane; -; 5-9;

Features [?]


Additional information [?]

Size range 240-390 amino acids
Related rules None
Fusion Nter: None Cter: None



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