HAMAP rule MF_01635
General rule information
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Accession | MF_01635 |
Dates | 14-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 25) |
Name | UbiA |
Scope(s) |
Bacteria Cyanobacteriota Pseudomonadota |
Template(s) | P0AGK1 (UBIA_ECOLI); Q55500 (PLQA_SYNY3); [ Recover all ] |
Triggered by |
case c? <OC:Bacteria>
HAMAP; MF_01635 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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case <OC:Pseudomonadota> | |
Identifier | UBIA |
Protein name | RecName: Full=4-hydroxybenzoate octaprenyltransferase; EC=2.5.1.39; AltName: Full=4-HB polyprenyltransferase; |
Gene name | Name=ubiA; |
else case <OC:Cyanobacteriota> | |
Identifier | PLQA |
Protein name | RecName: Full=4-hydroxybenzoate solanesyltransferase; EC=2.5.1.39; AltName: Full=4-HB polyprenyltransferase; |
Gene name | Name=plqA; |
end case |
Comments
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case <OC:Pseudomonadota> | |
FUNCTION | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. |
CATALYTIC ACTIVITY | Reaction=4-hydroxybenzoate + all-trans-octaprenyl diphosphate = 4- hydroxy-3-all-trans-octaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:27782, ChEBI:CHEBI:1617, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:57711; EC=2.5.1.39; |
PATHWAY | Cofactor biosynthesis; ubiquinone biosynthesis. |
else case <OC:Cyanobacteriota> | |
FUNCTION | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of plastoquinone-9 (PQ-9) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 4-hydroxy-3-solanesylbenzoate. |
CATALYTIC ACTIVITY | Reaction=4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4- hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:17709, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58391, ChEBI:CHEBI:84502; EC=2.5.1.39; |
end case | |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
SIMILARITY | Belongs to the UbiA prenyltransferase family. |
Keywords
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Cell membrane | |
Cell inner membrane | |
Magnesium | |
Membrane | |
Transferase | |
Transmembrane | |
Transmembrane helix | |
case <OC:Pseudomonadota> | |
Ubiquinone biosynthesis | |
end case |
Gene Ontology
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case <OCellular component:Pseudomonadota> | |
GO:0008412; Molecular function:4-hydroxybenzoate octaprenyltransferase activity | |
GO:0006744; Biological process:ubiquinone biosynthetic process | |
else case <OCellular component:Cyanobacteriota> | |
GO:0004659; Molecular function:prenyltransferase activity | |
GO:0010236; Biological process:plastoquinone biosynthetic process | |
end case | |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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PROSITE | PS00943; UBIA; 1; |
Pfam | PF01040; UbiA; 1; |
PRINTS | PR01415; ANKYRIN; 1; |
NCBIfam | TIGR01474; UbiA_proteo; 1; |
General | Transmembrane; -; 5-9; |
Features
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Additional information
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Size range | 240-390 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |