HAMAP rule MF_01639
General rule information
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Accession | MF_01639 |
Dates | 29-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 24) |
Name | PdxY |
Scope(s) |
Bacteria Actinomycetota Deinococci Pseudomonadota |
Template(s) | P77150 (PDXY_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01639 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PDXY |
Protein name | RecName: Full=Pyridoxal kinase PdxY; Short=PL kinase; EC=2.7.1.35; |
Gene name | Name=pdxY; |
Comments
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FUNCTION | Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. |
CATALYTIC ACTIVITY | Reaction=ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate; Xref=Rhea:RHEA:10224, ChEBI:CHEBI:15378, ChEBI:CHEBI:17310, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216, ChEBI:CHEBI:597326; EC=2.7.1.35; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
PATHWAY | Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1. |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the pyridoxine kinase family. PdxY subfamily. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function:magnesium ion binding |
GO:0005524; Molecular function:ATP binding |
GO:0008478; Molecular function:pyridoxal kinase activity |
GO:0009443; Biological process:pyridoxal 5'-phosphate salvage |
Cross-references
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Features
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From: PDXY_ECOLI (P77150) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 209 | 212 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R-x-x-[VLI] | ||||||||
BINDING | 45 | 46 | /ligand="substrate" | [TM]-Q | ||||||||
BINDING | 10 | 10 | /ligand="substrate" | S | ||||||||
BINDING | 112 | 112 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D | ||||||||
BINDING | 144 | 144 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[AV] | ||||||||
BINDING | 149 | 149 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
E | ||||||||
BINDING | 182 | 182 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
BINDING | 224 | 224 | /ligand="substrate" | D |
Additional information
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Size range | 283-299 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | SALTI contains a C-terminal deletion removing the last 68 aa, and may therefore be non-functional. This sequence is not shown in alignment and was not taken into account for the size range field. |