HAMAP

Accession	MF_01640
Dates	11-JUN-2007 (Created) 22-DEC-2010 (Last updated, Version 15)

Data class

Protein

Predictors

HAMAP; MF_01640; [distribution of match scores in UniProtKB];[seed alignment for MF_01640]

Names

E4P_dehydrog

Identifier

E4PD

Protein name

RecName: Full=D-erythrose-4-phosphate dehydrogenase; Short=E4PDH; EC=1.2.1.72;

Gene name

epd

FUNCTION: Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate (By similarity).

CATALYTIC ACTIVITY: D-erythrose 4-phosphate + NAD(+) + H(2)O = 4-phosphoerythronate + NADH.

PATHWAY: Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 1/5.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.

PROSITE	PS00071; GAPDH; 1;
Pfam	PF02800; Gp_dh_C; 1; PF00044; Gp_dh_N; 1;
PRINTS	PR00078; G3PDHDRGNASE; 1;
TIGRFAMs	TIGR01532; E4PD_g-proteo; 1;

Cytoplasm, NAD, Oxidoreductase, Pyridoxine biosynthesis.

GO:0048001; Molecular function: erythrose-4-phosphate dehydrogenase activity.
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process.
GO:0008615; Biological process: pyridoxine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: E4PD_ECOLI (P0A9B6)
Key		From		To		Description		Condition		FTGroup
NP_BIND		12		13		NAD (By similarity)		R-[IV]
REGION		154		156		Substrate binding (Potential)		S-C-T
REGION		213		214		Substrate binding (Potential)		T-[KR]
ACT_SITE		155		155		Nucleophile (By similarity)		C
BINDING (Optional)		81		81		NAD; via carbonyl oxygen (By similarity)		R
BINDING (Optional)		200		200		Substrate (Potential)		R
BINDING (Optional)		236		236		Substrate (Potential)		R
BINDING (Optional)		318		318		NAD (By similarity)		N
SITE		182		182		Activates thiol group during catalysis (By similarity)		H

Size range:	336-371 amino acids
Related UniRules:	None
Template:	P0A9B6 (E4PD_ECOLI)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None