HAMAP rule MF_01642
General rule information
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Accession | MF_01642 |
Dates | 7-NOV-2007 (Created)
14-MAY-2024 (Last updated, Version 28) |
Name | DapL_aminotrans_1 |
Scope(s) |
Bacteria Aquificia Bacteroidota Chlamydiota Chloroflexota Cyanobacteriota Clostridia Deltaproteobacteria Spirochaetota Archaea Methanobacteriales |
Template(s) | O84395 (DAPAT_CHLTR); Q6MDE0 (DAPAT_PARUW); Q55828 (DAPAT_SYNY3); O26158 (DAPAT_METTH); Q18T09 (DAPAT_DESHD); Q72NJ3 (DAPAT_LEPIC); Q2RK33 (DAPAT_MOOTA); Q5LC03 (DAPAT_BACFN); A3DK17 (DAPAT_ACET2); Q7NDX4 (DAPAT_GLOVI); A0LEA5 (DAPAT_SYNFM); [ Recover all ] |
Triggered by |
HAMAP; MF_01642 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DAPAT |
Protein name | RecName: Full=LL-diaminopimelate aminotransferase; Short=DAP-AT; Short=DAP-aminotransferase; Short=LL-DAP-aminotransferase; EC=2.6.1.83; |
Gene name | Name=dapL; |
Comments
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FUNCTION | Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. |
CATALYTIC ACTIVITY | Reaction=(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)- 2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate; Xref=Rhea:RHEA:23988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810, ChEBI:CHEBI:16845, ChEBI:CHEBI:29985, ChEBI:CHEBI:57609; EC=2.6.1.83; |
COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
PATHWAY | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1. |
SUBUNIT | Homodimer. |
SIMILARITY | Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily. |
Keywords
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Gene Ontology
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GO:0010285; Molecular function:L,L-diaminopimelate aminotransferase activity |
GO:0030170; Molecular function:pyridoxal phosphate binding |
GO:0033362; Biological process:lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway |
Cross-references
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Features
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From: DAPAT_CHLTR (O84395) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 104 | 105 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
[AST]-K | ||||||||
BINDING | 233 | 235 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
S-x-S | ||||||||
BINDING | 14 | 14 | /ligand="substrate" | Y | ||||||||
BINDING | 41 | 41 | /ligand="substrate" | G | ||||||||
BINDING | 71 | 71 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
Y | ||||||||
BINDING | 105 | 105 | /ligand="substrate" | K | ||||||||
BINDING | 128 | 128 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
[YF] | ||||||||
BINDING | 128 | 128 | /ligand="substrate" | [YF] | ||||||||
BINDING | 174 | 174 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
N | ||||||||
BINDING | 174 | 174 | /ligand="substrate" | N | ||||||||
BINDING | 205 | 205 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
Y | ||||||||
BINDING | 244 | 244 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
R | ||||||||
BINDING | 275 | 275 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
N | ||||||||
BINDING | 275 | 275 | /ligand="substrate" | N | ||||||||
BINDING | 369 | 369 | /ligand="substrate" | R | ||||||||
MOD_RES | 236 | 236 | /note="N6-(pyridoxal phosphate)lysine" | K |
Additional information
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Size range | 386-416 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |