Annotation rule MF_01644
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General rule information [?]

Accession MF_01644
Dates 14-JAN-2008 (Created)
27-NOV-2013 (Last updated, Version 9)
Name D_hydantoinase
Scope Bacteria; Enterobacteriaceae

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PHYDA
Protein name
RecName: Full=D-phenylhydantoinase;
EC=3.5.2.-;
AltName: Full=Hydantoin-utilizing enzyme HyuA;
Gene name
hyuA

Comments [?]

Function Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is unknown (By similarity).
Cofactor Binds 2 divalent metal cations per subunit (By similarity).
Subunit Homotetramer (By similarity).
Ptm Carbamylation allows a single lysine to coordinate two divalent metal cations (By similarity).
Similarity Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0016812; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides.

Cross-references [?]

Pfam PF01979; Amidohydro_1; 1;
TIGRFAMs TIGR02033; D-hydantoinase; 1;

Features [?]

From: PHYDA_ECOLI (Q46806)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     59     59       Divalent metal cation 1 (By similarity)     H  
METAL     61     61       Divalent metal cation 1 (By similarity)     H  
METAL     151     151       Divalent metal cation 1; via carbamate group (By similarity)     K  
METAL     151     151       Divalent metal cation 2; via carbamate group (By similarity)     K  
METAL     182     182       Divalent metal cation 2 (By similarity)     H  
METAL     239     239       Divalent metal cation 2 (By similarity)     H  
METAL     313     313       Divalent metal cation 1 (By similarity)     D  
BINDING     156     156       Substrate (By similarity)     Y  
BINDING     286     286       Substrate; via amide nitrogen and carbonyl oxygen (By similarity)     S  
BINDING     335     335       Substrate; via carbonyl oxygen (By similarity)     N  
MOD_RES     151     151       N6-carboxylysine (By similarity)     K  

Additional information [?]

Size range 461-461 amino acids
Related rules None
Template Q46806 (PHYDA_ECOLI)
Fusion None