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HAMAP rule MF_01645

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General rule information [?]

Accession MF_01645
Dates 14-JAN-2008 (Created)
1-JUN-2023 (Last updated, Version 28)
Name Hydantoinase
Scope(s) Bacteria
Template(s) P77671 (ALLB_ECOLI); O32137 (ALLB_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01645 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ALLB
Protein name RecName: Full=Allantoinase;
                 EC=3.5.2.5;
AltName: Full=Allantoin-utilizing enzyme;
case <OC:Bacillus>
Gene name Name=allB; Synonyms=pucH;
else
Gene name Name=allB;
end case

Comments [?]

FUNCTIONCatalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
CATALYTIC ACTIVITY Reaction=(S)-allantoin + H2O = allantoate + H(+); Xref=Rhea:RHEA:17029, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:17536; EC=3.5.2.5;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
PATHWAYNitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.
SUBUNITHomotetramer.
PTMCarboxylation allows a single lysine to coordinate two zinc ions.
SIMILARITYBelongs to the metallo-dependent hydrolases superfamily. Allantoinase family.

Keywords [?]


Gene Ontology [?]

GO:0004038; Molecular function:allantoinase activity
GO:0000256; Biological process:allantoin catabolic process

Cross-references [?]

Pfam PF01979; Amidohydro_1; 1;
NCBIfam TIGR00857; PyrC_multi; 1;

Features [?]

From: ALLB_ECOLI (P77671)
Key From To Description Tag Condition FTGroup
BINDING 59 59 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
H
BINDING 61 61 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
H
BINDING 146 146 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
/note="via carbamate group"
K
BINDING 146 146 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"
/note="via carbamate group"
K
BINDING 186 186 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"
H
BINDING 242 242 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="2"
H
BINDING 315 315 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="1"
D
MOD_RES 146 146 /note="N6-carboxylysine" K

Additional information [?]

Size range 438-457 amino acids
Related rules None
Fusion Nter: None Cter: None



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