HAMAP rule MF_01645
General rule information
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Accession | MF_01645 |
Dates | 14-JAN-2008 (Created)
1-JUN-2023 (Last updated, Version 28) |
Name | Hydantoinase |
Scope(s) |
Bacteria |
Template(s) | P77671 (ALLB_ECOLI); O32137 (ALLB_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_01645 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ALLB |
Protein name | RecName: Full=Allantoinase; EC=3.5.2.5; AltName: Full=Allantoin-utilizing enzyme; |
case <OC:Bacillus> | |
Gene name | Name=allB; Synonyms=pucH; |
else | |
Gene name | Name=allB; |
end case |
Comments
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FUNCTION | Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring. |
CATALYTIC ACTIVITY | Reaction=(S)-allantoin + H2O = allantoate + H(+); Xref=Rhea:RHEA:17029, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:17536; EC=3.5.2.5; |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; |
PATHWAY | Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. |
SUBUNIT | Homotetramer. |
PTM | Carboxylation allows a single lysine to coordinate two zinc ions. |
SIMILARITY | Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. |
Keywords
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Gene Ontology
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GO:0004038; Molecular function:allantoinase activity |
GO:0000256; Biological process:allantoin catabolic process |
Cross-references
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Features
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From: ALLB_ECOLI (P77671) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 59 | 59 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
BINDING | 61 | 61 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
BINDING | 146 | 146 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /note="via carbamate group" |
K | ||||||||
BINDING | 146 | 146 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /note="via carbamate group" |
K | ||||||||
BINDING | 186 | 186 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
H | ||||||||
BINDING | 242 | 242 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
H | ||||||||
BINDING | 315 | 315 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
D | ||||||||
MOD_RES | 146 | 146 | /note="N6-carboxylysine" | K |
Additional information
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Size range | 438-457 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |