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HAMAP rule MF_01648

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General rule information [?]

Accession MF_01648
Dates 17-APR-2008 (Created)
19-NOV-2022 (Last updated, Version 24)
Name HcaE
Scope(s) Bacteria
Enterobacterales
Template(s) P0ABR5 (HCAE_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01648 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HCAE
Protein name RecName: Full=3-phenylpropionate/cinnamic acid dioxygenase subunit alpha;
                 EC=1.14.12.19;
Gene name Name=hcaE;

Comments [?]

FUNCTIONPart of the multicomponent 3-phenylpropionate dioxygenase. Converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into 3- phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid- dihydrodiol (CI-dihydrodiol), respectively.
CATALYTIC ACTIVITY Reaction=3-phenylpropanoate + H(+) + NADH + O2 = 3-(cis-5,6- dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+); Xref=Rhea:RHEA:20357, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:51057, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:60087; EC=1.14.12.19;
CATALYTIC ACTIVITY Reaction=(E)-cinnamate + H(+) + NADH + O2 = (2E)-3-(cis-5,6- dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+); Xref=Rhea:RHEA:25058, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15669, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:61451; EC=1.14.12.19;
COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation.;
COFACTOR Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster per subunit.
PATHWAYAromatic compound metabolism; 3-phenylpropanoate degradation.
SUBUNITThis dioxygenase system consists of four proteins: the two subunits of the hydroxylase component (HcaE and HcaF), a ferredoxin (HcaC) and a ferredoxin reductase (HcaD).
SIMILARITYBelongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family.

Keywords [?]


Gene Ontology [?]

GO:0005506; Molecular function:iron ion binding
GO:0008695; Molecular function:3-phenylpropionate dioxygenase activity
GO:0019439; Biological process:aromatic compound catabolic process

Cross-references [?]

PROSITE PS51296; RIESKE; 1;
PROSITE PS00570; RING_HYDROXYL_ALPHA; 1;
Pfam PF00355; Rieske; 1;
Pfam PF00848; Ring_hydroxyl_A; 1;
PRINTS PR00090; RNGDIOXGNASE; 1;

Features [?]

From: HCAE_ECOLI (P0ABR5)
Key From To Description Tag Condition FTGroup
BINDING 85 85 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C
BINDING 87 87 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
H
BINDING 105 105 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
C
BINDING 108 108 /ligand="[2Fe-2S] cluster"
/ligand_id="ChEBI:CHEBI:190135"
H
BINDING 213 213 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
H
BINDING 218 218 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
H

Additional information [?]

Size range 453-453 amino acids
Related rules None
Fusion Nter: None Cter: None



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