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HAMAP rule MF_01652

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General rule information [?]

Accession MF_01652
Dates 29-APR-2008 (Created)
17-FEB-2023 (Last updated, Version 25)
Name MhpA
Scope(s) Bacteria
Mycobacteriales
Pseudomonadota
Template(s) P77397 (MHPA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01652 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MHPA
Protein name RecName: Full=3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase;
                 Short=3-HCI hydroxylase;
                 Short=3-HPP hydroxylase;
                 EC=1.14.13.127;
Gene name Name=mhpA;

Comments [?]

FUNCTIONCatalyzes the insertion of one atom of molecular oxygen into position 2 of the phenyl ring of 3-(3-hydroxyphenyl)propionate (3-HPP) and hydroxycinnamic acid (3HCI).
CATALYTIC ACTIVITY Reaction=3-(3-hydroxyphenyl)propanoate + H(+) + NADH + O2 = 3-(2,3- dihydroxyphenyl)propanoate + H2O + NAD(+); Xref=Rhea:RHEA:24785, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:46951, ChEBI:CHEBI:57277, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.14.13.127;
CATALYTIC ACTIVITY Reaction=(2E)-3-(3-hydroxyphenyl)prop-2-enoate + H(+) + NADH + O2 = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD(+); Xref=Rhea:RHEA:27846, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:47928, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:58642; EC=1.14.13.127;
COFACTOR Name=FAD; Xref=ChEBI:CHEBI:57692;
PATHWAYAromatic compound metabolism; 3-phenylpropanoate degradation.
SIMILARITYBelongs to the PheA/TfdB FAD monooxygenase family.

Keywords [?]

Aromatic hydrocarbons catabolism
FAD
Flavoprotein
NAD
Oxidoreductase

Gene Ontology [?]

GO:0008688; Molecular function:3-(3-hydroxyphenyl)propionate hydroxylase activity
GO:0019622; Biological process:3-(3-hydroxy)phenylpropionate catabolic process

Cross-references [?]

Pfam PF01494; FAD_binding_3; 1;
PRINTS PR00420; RNGMNOXGNASE; 1;
PRINTS PR00368; FADPNR; 1;

Features [?]

From: MHPA_ECOLI (P77397)
Key From To Description Tag Condition FTGroup
BINDING 17 46 /ligand="FAD"
/ligand_id="ChEBI:CHEBI:57692"
BINDING 285 295 /ligand="FAD"
/ligand_id="ChEBI:CHEBI:57692"

Additional information [?]

Size range 439-622 amino acids
Related rules None
Fusion Nter: None Cter: None



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