HAMAP

Accession	MF_01653
Dates	29-APR-2008 (Created) 1-DEC-2011 (Last updated, Version 11)

Data class

Protein

Predictors

HAMAP; MF_01653; [distribution of match scores in UniProtKB];[seed alignment for MF_01653]

Names

MhpB

Identifier

MHPB

Protein name

RecName: Full=2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase; EC=1.13.11.16;

Gene name

mhpB

FUNCTION: Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively (By similarity).

CATALYTIC ACTIVITY: 3-(2,3-dihydroxyphenyl)propanoate + O(2) = 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate.

CATALYTIC ACTIVITY: (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O(2) = 2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate.

COFACTOR: Fe(2+) ion (By similarity).

PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.

SUBUNIT: Homotetramer (By similarity).

SIMILARITY: Belongs to the ligB/mhpB extradiol dioxygenase family.

Pfam	PF02900; LigB; 1;

Aromatic hydrocarbons catabolism, Dioxygenase, Iron, Oxidoreductase.

GO:0005506; Molecular function: iron ion binding.
GO:0047070; Molecular function: 3-carboxyethylcatechol 2,3-dioxygenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

From: MHPB_ECOLI (P0ABR9)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		115		115		Proton donor (By similarity)		H
ACT_SITE		179		179		Proton acceptor (By similarity)		H

Size range:	311-331 amino acids
Related UniRules:	None
Template:	P0ABR9 (MHPB_ECOLI)
Scope:	Bacteria; Actinobacteria Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in DECAR, PSEPU
Plasmid encoded:	in PSEPU