Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https
Annotation rule MF_01653
Send feedback

General rule information [?]

Accession MF_01653
Dates 29-APR-2008 (Created)
10-OCT-2014 (Last updated, Version 15)
Name MhpB
Scope Bacteria; Actinobacteria
Bacteria; Proteobacteria
Template P0ABR9 (MHPB_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase;
AltName: Full=3-carboxyethylcatechol 2,3-dioxygenase;
Gene name

Comments [?]

Function Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
Catalytic activity 3-(2,3-dihydroxyphenyl)propanoate + O(2) = (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate.
(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O(2) = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate.
Cofactor Fe(2+)
Pathway Aromatic compound metabolism; 3-phenylpropanoate degradation.
Subunit Homotetramer.
Similarity Belongs to the LigB/MhpB extradiol dioxygenase family.

Keywords [?]

Gene Ontology [?]

GO:0005506; Molecular function: iron ion binding.
GO:0047070; Molecular function: 3-carboxyethylcatechol 2,3-dioxygenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Pfam PF02900; LigB; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     115     115       Proton donor     H  
ACT_SITE     179     179       Proton acceptor     H  

Additional information [?]

Size range 311-331 amino acids
Related rules None
Fusion None