HAMAP rule MF_01657
General rule information
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Accession | MF_01657 |
Dates | 5-MAY-2008 (Created)
1-JUN-2023 (Last updated, Version 34) |
Name | Ac_ald_DH_ac |
Scope(s) |
Bacteria |
Template(s) | P77580 (ACDH_ECOLI); Q9KWS1 (ACDH_PSESP); Q79AF6 (ACDH4_PARXL); Q52060 (ACDH_PSEUF); Q53WH9 (ACDH_THET8); [ Recover all ] |
Triggered by |
HAMAP; MF_01657 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ACDH |
Protein name | RecName: Full=Acetaldehyde dehydrogenase; EC=1.2.1.10; AltName: Full=Acetaldehyde dehydrogenase [acetylating]; |
case <OC:Enterobacterales> | |
Gene name | Name=mhpF; |
end case |
Comments
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case <OC:Enterobacterales> | |
FUNCTION | Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. |
end case | |
CATALYTIC ACTIVITY | Reaction=acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:23288, ChEBI:CHEBI:15343, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.10; |
case <OC:Enterobacterales> | |
PATHWAY | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
SUBUNIT | Interacts with MhpE. |
end case | |
SIMILARITY | Belongs to the acetaldehyde dehydrogenase family. |
Keywords
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Gene Ontology
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GO:0008774; Molecular function:acetaldehyde dehydrogenase (acetylating) activity |
GO:0051287; Molecular function:NAD binding |
GO:0019439; Biological process:aromatic compound catabolic process |
Cross-references
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Pfam | PF09290; AcetDehyd-dimer; 1; |
Pfam | PF01118; Semialdhyde_dh; 1; |
NCBIfam | TIGR03215; Ac_ald_DH_ac; 1; |
PIRSF | PIRSF015689; Actaldh_dh_actl; 1; |
Features
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From: ACDH_PSEUF (Q52060) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 12 | 15 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[ST]-G-[NDAVS]-[IV] | ||||||||
BINDING | 163 | 171 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[SG]-x-G-[PI]-[GA]-[TS]-x-x-N | ||||||||
ACT_SITE | 132 | 132 | /note="Acyl-thioester intermediate" | C | ||||||||
BINDING | 290 | 290 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N |
Additional information
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Size range | 262-336 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |
Comments | This protein is present in multiple copies in some organisms, each one being located in a cluster involved in the degragation of a different aromatic compound. |