HAMAP

Accession	MF_01657
Dates	5-MAY-2008 (Created) 7-MAR-2011 (Last updated, Version 16)

Data class

Protein

Predictors

HAMAP; MF_01657; [distribution of match scores in UniProtKB];[seed alignment for MF_01657]

Names

Ac_ald_DH_ac

Identifier

ACDH

Protein name

RecName: Full=Acetaldehyde dehydrogenase; EC=1.2.1.10; AltName: Full=Acetaldehyde dehydrogenase [acetylating];

Gene name

mhpF

FUNCTION: Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity).

CATALYTIC ACTIVITY: Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH.

PATHWAY: Aromatic compound metabolism; 3-phenylpropanoate degradation.

SUBUNIT: Interacts with MhpE (By similarity).

SIMILARITY: Belongs to the acetaldehyde dehydrogenase family.

Pfam	PF09290; AcetDehyd-dimer; 1; PF01118; Semialdhyde_dh; 1;
TIGRFAMs	TIGR03215; ac_ald_DH_ac; 1;
PIRSF	PIRSF015689; Actaldh_dh_actl; 1;

Aromatic hydrocarbons catabolism, NAD, Oxidoreductase.

GO:0008774; Molecular function: acetaldehyde dehydrogenase (acetylating) activity.
GO:0051287; Molecular function: NAD binding.
GO:0019439; Biological process: aromatic compound catabolic process.

From: ACDH_PSEUF (Q52060)
Key		From		To		Description		Condition		FTGroup
NP_BIND (Optional)		12		15		NAD (By similarity)		[ST]-G-[NDAVS]-[IV]
NP_BIND (Optional)		163		171		NAD (By similarity)		[SG]-x-G-[PI]-[GA]-[TS]-x-x-N
BINDING		290		290		NAD (By similarity)		N

Size range:	262-336 amino acids
Related UniRules:	None
Template:	P77580 (ACDH_ECOLI); Q9KWS1 (ACDH_PSESP); Q79AF6 (ACDH4_BURXL); Q52060 (ACDH_PSEUF): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in AZOSB, AZOVD, BURCJ, BURP8, BURS3, BURVG, BURXL, COMTE, DECAR, FRASN, METPP, MYCA9, MYCMM, MYCS2, MYCSJ, MYCSK, MYCSS, MYCUA, MYCVP, NOCFA, NOCSJ, NOVAD, PSEP1, PSEPS, PSEPW, CUPNH, RALME, RHOE4, RHOOB, RHOSR, SALAI, SPHWW
Plasmid encoded:	in GEOSE, BURCE, BURVG, MYCSK, MYCSS, NOVAD, POLNA, POLSJ, PSEPU, RALME, RALSO, RHOOB, RHOSR, SPHAR, SPHWW, THET8
Comments:	This protein is present in multiple copies in some organisms, each one being located in a cluster involved in the degragation of a different aromatic compound.