HAMAP

Accession	MF_01659
Dates	23-MAY-2008 (Created) 19-AUG-2011 (Last updated, Version 11)

Name

MenD

Scope

Bacteria Archaea

Triggered by

HAMAP; MF_01659 (Get profile general information and statistics)

Identifier

MEND

Protein name

RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; EC=2.2.1.9; AltName: Full=Menaquinone biosynthesis protein MenD;

Gene name

menD

FUNCTION	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) (By similarity).
CATALYTIC ACTIVITY	Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2).
COFACTOR	Magnesium or manganese (By similarity).
	Binds 1 thiamine pyrophosphate per subunit (By similarity).
PATHWAY	Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate; step 2/8.
SUBUNIT	Homodimer (By similarity).
SIMILARITY	Belongs to the TPP enzyme family. MenD subfamily.

Magnesium
Manganese
Menaquinone biosynthesis
Metal-binding
Thiamine pyrophosphate
Transferase

GO:0000287; Molecular function: magnesium ion binding.
GO:0030145; Molecular function: manganese ion binding.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0009234; Biological process: menaquinone biosynthetic process.

Pfam	PF02776; TPP_enzyme_N; 1;
TIGRFAMs	TIGR00173; MenD; 1;

Size range:	508-619 amino acids
Related Rules:	None
Template:	P17109 (MEND_ECOLI)
Fusion:	None

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