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Annotation rule MF_01659
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General rule information [?]

Accession MF_01659
Dates 23-MAY-2008 (Created)
10-OCT-2014 (Last updated, Version 15)
Name MenD
Scope Bacteria
Template P17109 (MEND_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

case not <OC:Cyanobacteria>
Protein name
RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase;
Short=SEPHCHC synthase;
AltName: Full=Menaquinone biosynthesis protein MenD;
else case <OC:Cyanobacteria>
Protein name
RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase;
Short=SEPHCHC synthase;
end case
Gene name

Comments [?]

Function Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
Catalytic activity Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2).
Cofactor Mg(2+)
thiamine diphosphate
Note: Binds 1 thiamine pyrophosphate per subunit.
Pathway Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.
case not <OC:Cyanobacteria>
Pathway Quinol/quinone metabolism; menaquinone biosynthesis.
else case <OC:Cyanobacteria>
Pathway Cofactor biosynthesis; phylloquinone biosynthesis.
end case
Subunit Homodimer.
Similarity Belongs to the TPP enzyme family. MenD subfamily.

Keywords [?]

case not <OC:Cyanobacteria>
end case

Gene Ontology [?]

GO:0070204; Molecular function: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0030145; Molecular function: manganese ion binding.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
case not <OC:Cyanobacteria>
GO:0009234; Biological process: menaquinone biosynthetic process.
else case <OC:Cyanobacteria>
GO:0042372; Biological process: phylloquinone biosynthetic process.
end case

Cross-references [?]

Pfam PF02776; TPP_enzyme_N; 1;
TIGRFAMs TIGR00173; MenD; 1;

Additional information [?]

Size range 497-700 amino acids
Related rules None
Fusion None