Annotation rule MF_01659
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General rule information [?]

Accession MF_01659
Dates 23-MAY-2008 (Created)
19-AUG-2011 (Last updated, Version 11)
Name MenD
Scope Bacteria
Archaea

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MEND
Protein name
RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase;
Short=SEPHCHC synthase;
EC=2.2.1.9;
AltName: Full=Menaquinone biosynthesis protein MenD;
Gene name
menD

Comments [?]

Function Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) (By similarity).
Catalytic activity Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO(2).
Cofactor Magnesium or manganese (By similarity).
Binds 1 thiamine pyrophosphate per subunit (By similarity).
Pathway Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate; step 2/8.
Subunit Homodimer (By similarity).
Similarity Belongs to the TPP enzyme family. MenD subfamily.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0030145; Molecular function: manganese ion binding.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0009234; Biological process: menaquinone biosynthetic process.

Cross-references [?]

Pfam PF02776; TPP_enzyme_N; 1;
TIGRFAMs TIGR00173; MenD; 1;

Additional information [?]

Size range 508-619 amino acids
Related rules None
Template P17109 (MEND_ECOLI)
Fusion None