HAMAP

Accession	MF_01660
Dates	23-MAY-2008 (Created) 25-NOV-2009 (Last updated, Version 6)

Data class

Protein

Predictors

HAMAP; MF_01660; [distribution of match scores in UniProtKB];[seed alignment for MF_01660]

Names

MenH

Identifier

MENH

Protein name

RecName: Full=2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Short=SHCHC synthase; EC=4.2.99.20;

Gene name

menH

FUNCTION: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity).

CATALYTIC ACTIVITY: 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.

PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 3/8.

SUBUNIT: Monomer (By similarity).

SIMILARITY: Belongs to the AB hydrolase superfamily. MenH family.

Pfam	PF00561; Abhydrolase_1; 1;

Lyase, Menaquinone biosynthesis.

GO:0016829; Molecular function: lyase activity.
GO:0009234; Biological process: menaquinone biosynthetic process.

Size range:	252-278 amino acids
Related UniRules:	None
Template:	P37355 (MENH_ECOLI)
Scope:	Bacteria; Enterobacteriales
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None