HAMAP rule MF_01665
General rule information
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| Accession | MF_01665 |
| Dates | 8-JUL-2008 (Created)
19-NOV-2022 (Last updated, Version 17) |
| Name | HemeA_synth_type2 |
| Scope(s) |
Bacteria Flavobacteriia Alphaproteobacteria Betaproteobacteria |
| Template(s) | P12946 (CTAA_BACSU); Q3IXW9 (CTAA_CERS4); [ Recover all ] |
| Triggered by |
HAMAP; MF_01665 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CTAA |
| Protein name | RecName: Full=Heme A synthase; Short=HAS; EC=1.17.99.9; AltName: Full=Cytochrome aa3-controlling protein; |
| Gene name | Name=ctaA; |
Comments
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| FUNCTION | Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A. |
| CATALYTIC ACTIVITY | Reaction=2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a; Xref=Rhea:RHEA:63388, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:60530, ChEBI:CHEBI:61715; EC=1.17.99.9; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:63389; |
| COFACTOR | Name=heme b; Xref=ChEBI:CHEBI:60344; |
| PATHWAY | Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1. |
| SUBUNIT | Interacts with CtaB. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the COX15/CtaA family. Type 2 subfamily. |
Keywords
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| Cell membrane |
| Heme biosynthesis |
| Iron |
| Membrane |
| Metal-binding |
| Oxidoreductase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0006784; Biological process:heme A biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF02628; COX15-CtaA; 1; |
| General | Transmembrane; -; 8; |
Features
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| From: CTAA_CERS4 (Q3IXW9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 300 | 300 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
H | ||||||||
| BINDING | 360 | 360 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
H | ||||||||
Additional information
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| Size range | 325-391 amino acids |
| Related rules |
MF_01664 |
| Fusion | Nter: None Cter: None |
| Comments | COX15/ctaA type 1 subfamily in MF_01664. |