HAMAP

Accession	MF_01667
Dates	5-AUG-2008 (Created) 29-MAR-2010 (Last updated, Version 4)

Data class

Protein

Predictors

HAMAP; MF_01667; [distribution of match scores in UniProtKB];[seed alignment for MF_01667]

Names

2-Hacid_dh_C_GhrB

Identifier

GHRB

Protein name

RecName: Full=Glyoxylate/hydroxypyruvate reductase B; EC=1.1.1.79; EC=1.1.1.81;

Gene name

ghrB

FUNCTION: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively (By similarity).

CATALYTIC ACTIVITY: Glycolate + NADP(+) = glyoxylate + NADPH.

CATALYTIC ACTIVITY: D-glycerate + NAD(P)(+) = hydroxypyruvate + NAD(P)H.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.

PROSITE	PS00065; D_2_HYDROXYACID_DH_1; 1; PS00670; D_2_HYDROXYACID_DH_2; 1; PS00671; D_2_HYDROXYACID_DH_3; 1;
Pfam	PF00389; 2-Hacid_dh; 1; PF02826; 2-Hacid_dh_C; 1;

Cytoplasm, NAD, NADP, Oxidoreductase.

GO:0016618; Molecular function: hydroxypyruvate reductase activity.
GO:0030267; Molecular function: glyoxylate reductase (NADP) activity.
GO:0005886; Cellular component: plasma membrane.

From: GHRB_ECOLI (P37666)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		237		237		By similarity		R
ACT_SITE		266		266		By similarity		E
ACT_SITE		285		285		Proton donor (By similarity)		H

Size range:	320-326 amino acids
Related UniRules:	None
Template:	P37666 (GHRB_ECOLI)
Scope:	Bacteria; Enterobacteriales
Fusion:	Nter: None; Cter: None
Duplicate:	in ECOLI
Plasmid encoded:	None