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HAMAP rule MF_01667

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General rule information [?]

Accession MF_01667
Dates 5-AUG-2008 (Created)
13-JAN-2021 (Last updated, Version 11)
Name 2_Hacid_dh_C_GhrB
Scope(s) Bacteria
Enterobacterales
Template(s) P37666 (GHRB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01667 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GHRB
Protein name RecName: Full=Glyoxylate/hydroxypyruvate reductase B;
                 EC=1.1.1.79;
                 EC=1.1.1.81;
Gene name Name=ghrB;

Comments [?]

FUNCTIONCatalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
CATALYTIC ACTIVITY Reaction=glycolate + NADP(+) = glyoxylate + H(+) + NADPH; Xref=Rhea:RHEA:10992, ChEBI:CHEBI:15378, ChEBI:CHEBI:29805, ChEBI:CHEBI:36655, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.79;
CATALYTIC ACTIVITY Reaction=(R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH; Xref=Rhea:RHEA:17905, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:17180, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.81;
CATALYTIC ACTIVITY Reaction=(R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH; Xref=Rhea:RHEA:18657, ChEBI:CHEBI:15378, ChEBI:CHEBI:16659, ChEBI:CHEBI:17180, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.81;
SUBUNITHomodimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.

Keywords [?]


Gene Ontology [?]

GO:0016618; Molecular function:hydroxypyruvate reductase activity
GO:0030267; Molecular function:glyoxylate reductase (NADP+) activity
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1;
PROSITE PS00670; D_2_HYDROXYACID_DH_2; 1;
PROSITE PS00671; D_2_HYDROXYACID_DH_3; 1;
Pfam PF00389; 2-Hacid_dh; 1;
Pfam PF02826; 2-Hacid_dh_C; 1;

Features [?]

From: GHRB_ECOLI (P37666)
Key From To Description Tag Condition FTGroup
ACT_SITE 237 237 R
ACT_SITE 266 266 E
ACT_SITE 285 285 /note="Proton donor" H

Additional information [?]

Size range 320-326 amino acids
Related rules None
Fusion Nter: None Cter: None



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