HAMAP rule MF_01669
General rule information
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Accession | MF_01669 |
Dates | 29-SEP-2008 (Created)
13-JAN-2023 (Last updated, Version 14) |
Name | IolD |
Scope(s) |
Bacteria Bacillota |
Template(s) | P42415 (IOLD_BACSU); [ Recover all ] |
Triggered by |
HAMAP; MF_01669 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | IOLD |
Protein name | RecName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; Short=THcHDO hydrolase; EC=3.7.1.22; |
Gene name | Name=iolD; |
Comments
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FUNCTION | Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG). |
CATALYTIC ACTIVITY | Reaction=3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D- glucuronate + H(+); Xref=Rhea:RHEA:25836, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28446, ChEBI:CHEBI:58852; EC=3.7.1.22; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
COFACTOR | Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Note=Binds 1 thiamine pyrophosphate per subunit.; |
PATHWAY | Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 3/7. |
SIMILARITY | Belongs to the TPP enzyme family. |
Keywords
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Gene Ontology
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GO:0000287; Molecular function:magnesium ion binding |
GO:0016787; Molecular function:hydrolase activity |
GO:0030976; Molecular function:thiamine pyrophosphate binding |
GO:0019310; Biological process:inositol catabolic process |
Cross-references
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PROSITE | PS00187; TPP_ENZYMES; 1; |
Pfam | PF02775; TPP_enzyme_C; 1; |
Pfam | PF00205; TPP_enzyme_M; 1; |
Pfam | PF02776; TPP_enzyme_N; 1; |
Features
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From: IOLD_BACSU (P42415) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 442 | 522 | /note="Thiamine pyrophosphate binding" | |||||||||
BINDING | 493 | 493 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
BINDING | 520 | 520 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
N | ||||||||
BINDING | 66 | 66 | /ligand="thiamine diphosphate" /ligand_id="ChEBI:CHEBI:58937" |
E |
Additional information
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Size range | 637-645 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |