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HAMAP rule MF_01669

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General rule information [?]

Accession MF_01669
Dates 29-SEP-2008 (Created)
13-JAN-2023 (Last updated, Version 14)
Name IolD
Scope(s) Bacteria
Bacillota
Template(s) P42415 (IOLD_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01669 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier IOLD
Protein name RecName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase;
                 Short=THcHDO hydrolase;
                 EC=3.7.1.22;
Gene name Name=iolD;

Comments [?]

FUNCTIONInvolved in the cleavage of the C1-C2 bond of 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG).
CATALYTIC ACTIVITY Reaction=3D-3,5/4-trihydroxycyclohexane-1,2-dione + H2O = 5-deoxy-D- glucuronate + H(+); Xref=Rhea:RHEA:25836, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28446, ChEBI:CHEBI:58852; EC=3.7.1.22;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
COFACTOR Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Note=Binds 1 thiamine pyrophosphate per subunit.;
PATHWAYPolyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 3/7.
SIMILARITYBelongs to the TPP enzyme family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0016787; Molecular function:hydrolase activity
GO:0030976; Molecular function:thiamine pyrophosphate binding
GO:0019310; Biological process:inositol catabolic process

Cross-references [?]

PROSITE PS00187; TPP_ENZYMES; 1;
Pfam PF02775; TPP_enzyme_C; 1;
Pfam PF00205; TPP_enzyme_M; 1;
Pfam PF02776; TPP_enzyme_N; 1;

Features [?]

From: IOLD_BACSU (P42415)
Key From To Description Tag Condition FTGroup
REGION 442 522 /note="Thiamine pyrophosphate binding"
BINDING 493 493 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
D
BINDING 520 520 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
N
BINDING 66 66 /ligand="thiamine diphosphate"
/ligand_id="ChEBI:CHEBI:58937"
E

Additional information [?]

Size range 637-645 amino acids
Related rules None
Fusion Nter: None Cter: None



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