HAMAP

Accession	MF_01669
Dates	29-SEP-2008 (Created) 20-DEC-2010 (Last updated, Version 6)

Data class

Protein

Predictors

HAMAP; MF_01669; [distribution of match scores in UniProtKB];[seed alignment for MF_01669]

Names

IolD

Identifier

IOLD

Protein name

RecName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase; Short=THcHDO hydrolase; EC=3.7.1.n2;

Gene name

iolD

FUNCTION: Involved in the cleavage of the C1-C2 bond of 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy-glucuronate (5DG) (By similarity).

CATALYTIC ACTIVITY: 3,5/4-trihydroxycyclohexa-1,2-dione + H(2)O = 5-deoxy-glucuronic acid.

COFACTOR: Binds 1 magnesium ion per subunit (By similarity).

COFACTOR: Binds 1 thiamine pyrophosphate per subunit (By similarity).

PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 3/7.

SIMILARITY: Belongs to the TPP enzyme family.

PROSITE	PS00187; TPP_ENZYMES; 1;
Pfam	PF02775; TPP_enzyme_C; 1; PF00205; TPP_enzyme_M; 1; PF02776; TPP_enzyme_N; 1;

Hydrolase, Magnesium, Metal-binding, NAD, Thiamine pyrophosphate.

GO:0000287; Molecular function: magnesium ion binding.
GO:0016787; Molecular function: hydrolase activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0019310; Biological process: inositol catabolic process.

From: IOLD_BACSU (P42415)
Key		From		To		Description		Condition		FTGroup
REGION		442		522		Thiamine pyrophosphate binding (By similarity)
METAL		493		493		Magnesium (By similarity)		D
METAL		520		520		Magnesium (By similarity)		N
BINDING		66		66		Thiamine pyrophosphate (By similarity)		E

Size range:	637-645 amino acids
Related UniRules:	None
Template:	P42415 (IOLD_BACSU)
Scope:	Bacteria; Firmicutes
Fusion:	Nter: None; Cter: None
Duplicate:	in BACCZ
Plasmid encoded:	in BACCZ