HAMAP

Accession	MF_01670
Dates	29-SEP-2008 (Created) 17-FEB-2010 (Last updated, Version 4)

Data class

Protein

Predictors

HAMAP; MF_01670; [distribution of match scores in UniProtKB];[seed alignment for MF_01670]

Names

IolA

Identifier

IOLA

Protein name

RecName: Full=Methylmalonate semialdehyde dehydrogenase [acylating]; Short=MMSA dehydrogenase; Short=MMSDH; Short=MSDH; EC=1.2.1.27; AltName: Full=Malonate semialdehyde dehydrogenase [acetylating]; Short=MSA dehydrogenase; EC=1.2.1.18;

Gene name

iolA

FUNCTION: Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively (By similarity).

CATALYTIC ACTIVITY: 3-oxopropanoate + CoA + NAD(P)(+) = acetyl-CoA + CO(2) + NAD(P)H.

CATALYTIC ACTIVITY: 2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) = propanoyl-CoA + HCO(3)(-) + NADH.

PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7.

SUBUNIT: Homotetramer (By similarity).

SIMILARITY: Belongs to the aldehyde dehydrogenase family. IolA subfamily.

PROSITE	PS00070; ALDEHYDE_DEHYDR_CYS; 1; PS00687; ALDEHYDE_DEHYDR_GLU; 1;
Pfam	PF00171; Aldedh; 1;
TIGRFAMs	TIGR01722; MMSDH; 1;

NAD, Oxidoreductase.

GO:0004491; Molecular function: methylmalonate-semialdehyde dehydrogenase (acylating) activity.
GO:0018478; Molecular function: malonate-semialdehyde dehydrogenase (acetylating) activity.
GO:0019310; Biological process: inositol catabolic process.

From: IOLA_BACSU (P42412)
Key		From		To		Description		Condition		FTGroup
NP_BIND		176		180		NAD (By similarity)		K-[PT]-S-E-[KR]
ACT_SITE		284		284		Nucleophile (By similarity)		C
BINDING		382		382		NAD (By similarity)		E

Size range:	483-492 amino acids
Related UniRules:	None
Template:	P42412 (IOLA_BACSU)
Scope:	Bacteria; Firmicutes
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAH, BACAN, BACCZ, BACHK, BACLD, BACSK, BACWK, GEOKA, GEOTN, OCEIH
Plasmid encoded:	in BACCZ