HAMAP rule MF_01675
General rule information
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| Accession | MF_01675 |
| Dates | 7-OCT-2008 (Created)
1-JUN-2023 (Last updated, Version 18) |
| Name | Sep_Cys_tRNA_synth |
| Scope(s) |
Archaea |
| Template(s) | Q59072 (SPSS_METJA); O30207 (SPSS1_ARCFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01675 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | SPSS |
| Protein name | RecName: Full=O-phospho-L-seryl-tRNA:Cys-tRNA synthase; EC=2.5.1.73; AltName: Full=Sep-tRNA:Cys-tRNA synthase; Short=SepCysS; |
Comments
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| FUNCTION | Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L- cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)). |
| CATALYTIC ACTIVITY | Reaction=H(+) + hydrogen sulfide + O-phospho-L-seryl-tRNA(Cys) = L- cysteinyl-tRNA(Cys) + phosphate; Xref=Rhea:RHEA:25686, Rhea:RHEA- COMP:9679, Rhea:RHEA-COMP:9719, ChEBI:CHEBI:15378, ChEBI:CHEBI:29919, ChEBI:CHEBI:43474, ChEBI:CHEBI:78517, ChEBI:CHEBI:78551; EC=2.5.1.73; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| SUBUNIT | Homodimer. Interacts with SepRS. |
| SIMILARITY | Belongs to the SepCysS family. |
Keywords
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Gene Ontology
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| GO:0043766; Molecular function:Sep-tRNA:Cys-tRNA synthase activity |
Cross-references
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Features
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| From: SPSS1_ARCFU (O30207) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 78 | 79 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
A-R | ||||||||
| BINDING | 206 | 208 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
S-G-H | ||||||||
| BINDING | 183 | 183 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
N | ||||||||
| MOD_RES | 209 | 209 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 371-463 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus and Methanopyrus kandleri use the SepRS?SepCysS pathway obligatorily for synthesis of Cys-tRNACys, whereas many others (for example, Methanococcus maripaludis and Archaeoglobus fulgidus) contain genes for both the CysRS and the SepRS?SepCysS pathways (PMID:16380427). |