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HAMAP annotation rule: MF_01678
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General rule information

Accession MF_01678
Dates 21-OCT-2008 (Created)
22-OCT-2010 (Last updated, Version 11)
Data class Protein
Predictors HAMAP; MF_01678; [distribution of match scores in UniProtKB];[seed alignment for MF_01678]
Names Salvage_MtnA


Propagated annotation

Identifier, protein and gene names
Identifier MTNA

case <OC:Archaea>
Protein name
RecName: Full=Putative methylthioribose-1-phosphate isomerase;
Short=M1Pi;
Short=MTR-1-P isomerase;
EC=5.3.1.23;
AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;
AltName: Full=MTNA-like protein;
Short=aMTNA;

else
Protein name
RecName: Full=Methylthioribose-1-phosphate isomerase;
Short=M1Pi;
Short=MTR-1-P isomerase;
EC=5.3.1.23;
AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;
end case


case <OC:Bacteria>
Gene name mtnA
end case

Comments
FUNCTION: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity).
CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.

case <OC:Bacteria>
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.
end case


case <OC:Bacillaceae>
SUBUNIT: Homodimer.
end case

SIMILARITY: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
Cross-references
Pfam PF01008; IF-2B; 1;
TIGRFAMs TIGR00524; eIF-2B_rel; 1;
TIGR00512; salvage_mtnA; 1;
Keywords
Amino-acid biosynthesis, Isomerase, Methionine biosynthesis.
Gene Ontology
GO:0046523; Molecular function: S-methyl-5-thioribose-1-phosphate isomerase activity.
GO:0019284; Biological process: L-methionine biosynthetic process from S-adenosylmethionine.
Features
From: MTNA_BACSU (O31662)
Key     From     To       Description   Condition   FTGroup
REGION     51     53       Substrate binding (By similarity)      
REGION     250     251       Substrate binding (By similarity)      
ACT_SITE     240     240       Proton donor (By similarity)   D  
BINDING     94     94       Substrate (By similarity)   R  
BINDING     199     199       Substrate (By similarity)   Q  
SITE     160     160       Transition state stabilizer (By similarity)   [CS]  


Additional information

Size range: 311-552 amino acids
Related UniRules: None
Template: O31662 (MTNA_BACSU)
Scope: Bacteria
Archaea
Fusion: Nter: <Thioesterase>; Cter: None
Duplicate: in BACAH, BACAN, BACCR, BACCZ, BACHK, BACWK, PETMO, THELT
Plasmid encoded: in OCHA4, RHIME, SINMW

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UniProtKB rule member sequences