Annotation rule MF_01681
Send feedback

General rule information [?]

Accession MF_01681
Dates 24-OCT-2008 (Created)
2-MAR-2012 (Last updated, Version 10)
Name Salvage_MtnC
Scope Bacteria
Template P0C8L5 (MTNC_ENTAE)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MTNC
Protein name
RecName: Full=Enolase-phosphatase E1;
EC=3.1.3.77;
AltName: Full=2,3-diketo-5-methylthio-1-phosphopentane phosphatase;
Gene name
mtnC

Comments [?]

Function Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity).
Catalytic activity 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.
Cofactor Binds 1 magnesium ion per subunit (By similarity).
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate; step 3/6.
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate; step 4/6.
Subunit Monomer (By similarity).
Similarity Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0043715; Molecular function: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity.
GO:0043716; Molecular function: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity.
GO:0019284; Biological process: L-methionine biosynthetic process from S-adenosylmethionine.

Cross-references [?]

Pfam PF00702; Hydrolase; 1;
PRINTS PR00413; HADHALOGNASE; 1;
TIGRFAMs TIGR01691; Enolase-ppase; 1;
TIGR01549; HAD-SF-IA-v1; 1;
TIGR01509; HAD-SF-IA-v3; 1;

Additional information [?]

Size range 221-253 amino acids
Related rules None
Fusion None