HAMAP

Accession	MF_01681
Dates	24-OCT-2008 (Created) 8-JUN-2010 (Last updated, Version 8)

Data class

Protein

Predictors

HAMAP; MF_01681; [distribution of match scores in UniProtKB];[seed alignment for MF_01681]

Names

Salvage_MtnC

Identifier

MTNC

Protein name

RecName: Full=Enolase-phosphatase E1; EC=3.1.3.77; AltName: Full=2,3-diketo-5-methylthio-1-phosphopentane phosphatase;

Gene name

mtnC

FUNCTION: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity).

CATALYTIC ACTIVITY: 5-(methylthio)-2,3-dioxopentyl phosphate + H(2)O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.

COFACTOR: Binds 1 magnesium ion per subunit (By similarity).

PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.

PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.

SUBUNIT: Monomer (By similarity).

SIMILARITY: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family.

Pfam	PF00702; Hydrolase; 1;
PRINTS	PR00413; HADHALOGNASE; 1;
TIGRFAMs	TIGR01691; enolase-ppase; 1; TIGR01549; HAD-SF-IA-v1; 1; TIGR01509; HAD-SF-IA-v3; 1;

Amino-acid biosynthesis, Hydrolase, Magnesium, Metal-binding, Methionine biosynthesis.

GO:0000287; Molecular function: magnesium ion binding.
GO:0043715; Molecular function: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity.
GO:0043716; Molecular function: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity.
GO:0019284; Biological process: L-methionine biosynthetic process from S-adenosylmethionine.

Size range:	221-253 amino acids
Related UniRules:	None
Template:	P0C8L5 (MTNC_ENTAE)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None