Annotation rule MF_01688
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General rule information [?]

Accession MF_01688
Dates 8-APR-2009 (Created)
31-OCT-2011 (Last updated, Version 11)
Name Biphenyl_BphD
Scope Bacteria; Proteobacteria
Template P47229 (BPHD_BURXL)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
BPHD
Protein name
RecName: Full=2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase;
Short=HOPDA hydrolase;
EC=3.7.1.8;
AltName: Full=2,6-dioxo-6-phenylhexa-3-enoate hydrolase;
Gene name
bphD

Comments [?]

Function Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD) (By similarity).
Catalytic activity 2,6-dioxo-6-phenylhexa-3-enoate + H(2)O = benzoate + 2-oxopent-4-enoate.
Pathway Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl; step 4/4.
Subunit Homodimer (By similarity).
Similarity Belongs to the AB hydrolase superfamily. BphD family.

Keywords [?]


Gene Ontology [?]

GO:0018771; Molecular function: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;
TIGRFAMs TIGR03343; Biphenyl_bphD; 1;

Features [?]

From: BPHD_BURXL (P47229)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     42     43       Substrate binding (By similarity)     G-G  
ACT_SITE     112     112       Potential     S  
ACT_SITE     265     265       Proton acceptor (By similarity)     H  
BINDING     51     51       Substrate (By similarity)     N  
BINDING     111     111       Substrate (By similarity)     [KN]  
BINDING     180     180       Substrate; via carbonyl oxygen (By similarity)     [ST]  
BINDING     190     190       Substrate (By similarity)     R  
BINDING     266     266       Substrate (By similarity)     W  
SITE     112     112       Transition state stabilizer (By similarity)     S  

Additional information [?]

Size range 286-286 amino acids
Related rules None
Fusion None