HAMAP rule MF_01697
General rule information
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Accession | MF_01697 |
Dates | 20-SEP-2010 (Created)
1-JUN-2023 (Last updated, Version 14) |
Name | MshC |
Scope(s) |
Bacteria Actinomycetota |
Template(s) | A0QZY0 (MSHC_MYCS2); P9WJM9 (MSHC_MYCTU); [ Recover all ] |
Triggered by |
HAMAP; MF_01697 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MSHC |
Protein name | RecName: Full=L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Short=L-Cys:GlcN-Ins ligase; EC=6.3.1.13; AltName: Full=Mycothiol ligase; Short=MSH ligase; |
Gene name | Name=mshC; |
Comments
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FUNCTION | Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins. |
CATALYTIC ACTIVITY | Reaction=1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D- glucopyranoside + AMP + diphosphate + H(+); Xref=Rhea:RHEA:26176, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:35235, ChEBI:CHEBI:58886, ChEBI:CHEBI:58887, ChEBI:CHEBI:456215; EC=6.3.1.13; |
COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
SUBUNIT | Monomer. |
SIMILARITY | Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. |
Keywords
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Gene Ontology
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GO:0008270; Molecular function:zinc ion binding |
GO:0035446; Molecular function:cysteine-glucosaminylinositol ligase activity |
GO:0010125; Biological process:mycothiol biosynthetic process |
Cross-references
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Pfam | PF01406; tRNA-synt_1e; 1; |
PRINTS | PR00983; TRNASYNTHCYS; 1; |
NCBIfam | TIGR03447; Mycothiol_MshC; 1; |
Features
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From: MSHC_MYCS2 (A0QZY0) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 43 | 46 | /ligand="L-cysteinyl-5'-AMP" /ligand_id="ChEBI:CHEBI:144924" |
C-G-I-T | ||||||||
BINDING | 81 | 83 | /ligand="L-cysteinyl-5'-AMP" /ligand_id="ChEBI:CHEBI:144924" |
N-x-T | ||||||||
BINDING | 249 | 251 | /ligand="L-cysteinyl-5'-AMP" /ligand_id="ChEBI:CHEBI:144924" |
G-x-D | ||||||||
MOTIF | 45 | 55 | /note="'HIGH' region" | I-T-P-Y-D-[AS]-[AT]-H-[ILM]-G-H | ||||||||
MOTIF | 187 | 192 | /note="'ERGGDP' region" | [EDQ]-[HR]-G-G-D-P | ||||||||
MOTIF | 289 | 293 | /note="'KMSKS' region" | K-M-S-K-S | ||||||||
BINDING | 43 | 43 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | ||||||||
BINDING | 231 | 231 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | ||||||||
BINDING | 256 | 256 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
BINDING | 58 | 58 | /ligand="L-cysteinyl-5'-AMP" /ligand_id="ChEBI:CHEBI:144924" |
[ST] | ||||||||
BINDING | 227 | 227 | /ligand="L-cysteinyl-5'-AMP" /ligand_id="ChEBI:CHEBI:144924" |
W | ||||||||
BINDING | 283 | 283 | /ligand="L-cysteinyl-5'-AMP" /ligand_id="ChEBI:CHEBI:144924" |
[LIV] |
Additional information
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Size range | 384-520 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |