HAMAP rule MF_01707
General rule information
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| Accession | MF_01707 |
| Dates | 11-OCT-2004 (Created)
1-JUN-2023 (Last updated, Version 24) |
| Name | ABC_ATPase_CcmA |
| Scope(s) |
Bacteria Deinococci Pseudomonadota Eukaryota Arabidopsis Mitochondrion |
| Template(s) | P33931 (CCMA_ECOLI); [ Recover all ] |
| Triggered by |
PROSITE; PS51243 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CCMA |
| Protein name | RecName: Full=Cytochrome c biogenesis ATP-binding export protein CcmA; EC=7.6.2.5; AltName: Full=Heme exporter protein A; |
| Gene name | Name=ccmA; |
Comments
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| case <OC:Bacteria> or <OG:Mitochondrion> | |
| FUNCTION | Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O + heme b(in) = ADP + H(+) + heme b(out) + phosphate; Xref=Rhea:RHEA:19261, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:60344, ChEBI:CHEBI:456216; EC=7.6.2.5; |
| SUBUNIT | The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB). |
| SIMILARITY | Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. |
| end case | |
| case <OC:Bacteria> and (not defined <Property:Membrane> or <Property:Membrane=1>) | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| end case | |
| case <OC:Bacteria> and (defined <Property:Membrane> and <Property:Membrane=2>) | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
| end case | |
| case <OG:Mitochondrion> | |
| SUBCELLULAR LOCATION | Mitochondrion membrane; Peripheral membrane protein. |
| end case | |
Keywords
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| ATP-binding | |
| case <OC:Bacteria> and defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| case <OC:Bacteria> | |
| Cell membrane | |
| end case | |
| Membrane | |
| Nucleotide-binding | |
| Transport | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
| Cytochrome c-type biogenesis | |
Gene Ontology
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| GO:0022857; Molecular function:transmembrane transporter activity | |
| GO:0055085; Biological process:transmembrane transport | |
| case <OCellular component:Bacteria> | |
| GO:0005886; Cellular component:plasma membrane | |
| end case | |
| case <OG:Mitochondrion> | |
| GO:0031966; Cellular component:mitochondrial membrane | |
| end case | |
Cross-references
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| Pfam | PF00005; ABC_tran; 1; |
| NCBIfam | TIGR01189; CcmA; 1; |
| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
| PROSITE | PS50893; ABC_TRANSPORTER_2; 1; |
Features
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| # Fix case/else syntax |
Additional information
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| Size range | 192-345 amino acids |
| Related rules |
PRU01700 |
| Fusion | Nter: None Cter: ccmE |