HAMAP rule MF_01717
General rule information
[?]
| Accession | MF_01717 |
| Dates | 11-OCT-2006 (Created)
16-JUN-2022 (Last updated, Version 18) |
| Name | ABC_ATPase_MglA |
| Scope(s) |
Bacteria |
| Template(s) | P0AAG8 (MGLA_ECOLI); [ Recover all ] |
| Triggered by |
PROSITE; PS51260 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| case not <AnyFeature:PS51254> | |
| Identifier | MGLA |
| Protein name | RecName: Full=Galactose/methyl galactoside import ATP-binding protein MglA; EC=7.5.2.11; |
| Gene name | Name=mglA; |
| else | |
| Identifier | RGMG |
| Protein name | RecName: Full=Putative ribose/galactose/methyl galactoside import ATP-binding protein; EC=7.5.2.7; EC=7.5.2.11; |
| end case | |
Comments
[?]
| case <OC:Bacteria> and not <AnyFeature:PS51254> | |
| FUNCTION | Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system. |
| CATALYTIC ACTIVITY | Reaction=ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate; Xref=Rhea:RHEA:60156, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.11; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60157; |
| CATALYTIC ACTIVITY | Reaction=ATP + H2O + methyl beta-D-galactoside(out) = ADP + H(+) + methyl beta-D-galactoside(in) + phosphate; Xref=Rhea:RHEA:72531, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17540, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72532; |
| SUBUNIT | The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB). |
| SIMILARITY | Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family. |
| else | |
| FUNCTION | Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and/or methyl galactoside import. Responsible for energy coupling to the transport system. |
| CATALYTIC ACTIVITY | Reaction=ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate; Xref=Rhea:RHEA:29903, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:47013, ChEBI:CHEBI:456216; EC=7.5.2.7; |
| CATALYTIC ACTIVITY | Reaction=ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate; Xref=Rhea:RHEA:60156, ChEBI:CHEBI:4139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.11; |
| SIMILARITY | Belongs to the ABC transporter superfamily. Carbohydrate importer 2 (CUT2) (TC 3.A.1.2) family. |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
| end case | |
Keywords
[?]
| ATP-binding | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Membrane | |
| Nucleotide-binding | |
| Transport | |
| Sugar transport | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
Gene Ontology
[?]
| GO:0008643; Biological process:carbohydrate transport | |
| case not <AnyFeature:PS51254> | |
| GO:0005354; Molecular function:galactose transmembrane transporter activity | |
| end case | |
| case <OCellular component:Bacteria> | |
| GO:0005886; Cellular component:plasma membrane | |
| end case | |
Cross-references
[?]
| Pfam | PF00005; ABC_tran; 1; |
| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
| PROSITE | PS50893; ABC_TRANSPORTER_2; 2; |
| PROSITE | PS51254; RBSA; 1; |
Features
[?]
| # Fix case/else syntax |
Additional information
[?]
| Size range | 450-550 amino acids |
| Related rules |
PRU01700 |
| Fusion | Nter: None Cter: None |
| Comments | Some of these proteins are related to two differents sugar ABC import subfamilies, (PRU01716-PRU01717) therefore it is not possible to assign their substrate. For those cases a specific annotation is propagated. |