HAMAP rule MF_01720
General rule information
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| Accession | MF_01720 |
| Dates | 14-NOV-2006 (Created)
20-JUN-2023 (Last updated, Version 27) |
| Name | ABC_ATPase_TM_MacB |
| Scope(s) |
Bacteria |
| Template(s) | P75831 (MACB_ECOLI); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> and not <OC:Pseudomonadales>
PROSITE; PS51267 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MACB |
| Protein name | RecName: Full=Macrolide export ATP-binding/permease protein MacB; EC=7.6.2.-; |
| Gene name | Name=macB; |
Comments
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| case <OC:Gammaproteobacteria> | |
| FUNCTION | Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. |
| SUBUNIT | Homodimer. Part of the tripartite efflux system MacAB-TolC, which is composed of an inner membrane transporter, MacB, a periplasmic membrane fusion protein, MacA, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes. Interacts with MacA. |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| else case defined <Property:Membrane> and <Property:Membrane=2> | |
| FUNCTION | Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP- binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| else | |
| FUNCTION | Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family. |
Keywords
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| ATP-binding | |
| case <OC:Gammaproteobacteria> or (defined <Property:Membrane> and <Property:Membrane=2>) | |
| Cell inner membrane | |
| end case | |
| Nucleotide-binding | |
| Transport | |
| Antibiotic resistance | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
| Membrane | |
| Cell membrane | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0008559; Molecular function:ABC-type xenobiotic transporter activity |
| GO:1990961; Biological process:xenobiotic detoxification by transmembrane export across the plasma membrane |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF00005; ABC_tran; 1; |
| Pfam | PF02687; FtsX; 1; |
| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
| PROSITE | PS50893; ABC_TRANSPORTER_2; 1; |
| General | Transmembrane; -; 3-5; |
Features
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| # Fix case/else syntax |
Additional information
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| Size range | 640-715 amino acids |
| Related rules |
PRU01700 |
| Fusion | Nter: None Cter: None |