HAMAP

Accession	MF_01800
Dates	9-DEC-2003 (Created) 31-OCT-2011 (Last updated, Version 23)

Data class

Protein

Predictors

HAMAP; MF_01800; [distribution of match scores in UniProtKB];[seed alignment for MF_01800]

Names

MukB

Identifier

MUKB

Protein name

RecName: Full=Chromosome partition protein MukB; AltName: Full=Structural maintenance of chromosome-related protein;

Gene name

mukB

FUNCTION: Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity).

SUBUNIT: Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ (By similarity).

SUBCELLULAR LOCATION: Cytoplasm, nucleoid (By similarity). Note=Restricted to the nucleoid region (By similarity).

DOMAIN: The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer (By similarity).

SIMILARITY: Belongs to the SMC family. MukB subfamily.

Pfam	PF04310; MukB; 1;
General	Coiled_coil; -; 1-unlimited; trigger=Yes;

Cytoplasm, Cell cycle, Cell division, Chromosome partition, DNA-binding, DNA condensation, ATP-binding, Nucleotide-binding, Coiled coil.

GO:0005737; Cellular component: cytoplasm.
GO:0003677; Molecular function: DNA binding.
GO:0005524; Molecular function: ATP binding.
GO:0006260; Biological process: DNA replication.
GO:0007059; Biological process: chromosome segregation.

From: MUKB_ECOLI (P22523)
Key		From		To		Description		Condition		FTGroup
NP_BIND		34		41		ATP (Potential)		[AG]-x(4)-G-K-[ST]
REGION		666		783		Flexible hinge (By similarity)

Size range:	1479-1510 amino acids
Related UniRules:	MF_01801
Template:	P22523 (MUKB_ECOLI)
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Despite a low sequence conservation, mukB is strongly related to smc (MF_01801), and displays the same function.