HAMAP

Accession	MF_01810
Dates	17-NOV-2003 (Created) 8-DEC-2011 (Last updated, Version 25)

Data class

Protein

Predictors

HAMAP; MF_01810; [distribution of match scores in UniProtKB];[seed alignment for MF_01810]

Names

YidC_type1

Identifier

YIDC

Protein name

RecName: Full=Membrane protein insertase YidC; AltName: Full=Foldase YidC; AltName: Full=Membrane protein YidC; AltName: Full=Membrane integrase YidC;

Gene name

yidC

FUNCTION: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).

FUNCTION: Probably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid (By similarity).

SUBUNIT: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Pfam	PF02096; 60KD_IMP; 1;
PRINTS	PR00701; 60KDINNERMP; 1;
TIGRFAMs	TIGR03593; YidC_nterm; 1; TIGR03592; YidC_oxa1_C; 1;
General	Transmembrane; -; 4-8; trigger=Yes;

Chaperone, Membrane, Protein transport, Transmembrane, Transport, Cell membrane.

Cell inner membrane.

Transmembrane helix.

GO:0005886; Cellular component: plasma membrane.

Size range:

206-465 amino acids

Size range:

310-795 amino acids

Related UniRules:	MF_01811 (YIDC (supersedes the current rule))
Template:	P25714 (YIDC_ECOLI); P74155 (YIDC_SYNY3): [Recover all]
Scope:	Bacteria
Fusion:	Nter: <PDZ/DHR>; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	N-terminal PDZ/DHR fused in RHOBA. TIGR03593 describes a large N- terminal domain of unknown function not found in all members. In most Firmicutes (MF_01811), this protein is much shorter and is probably a lipoprotein. Chlamydiae have been annotated as lipoproteins. Streptomyces seem to only have 3 transmembrane helices.