Annotation rule MF_01810
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General rule information [?]

Accession MF_01810
Dates 17-NOV-2003 (Created)
8-DEC-2011 (Last updated, Version 25)
Name YidC_type1
Scope Bacteria
Templates P25714 (YIDC_ECOLI); P74155 (YIDC_SYNY3): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Membrane protein insertase YidC;
AltName: Full=Foldase YidC;
AltName: Full=Membrane protein YidC;
AltName: Full=Membrane integrase YidC;
Gene name

Comments [?]

Function Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).
case <OC:Cyanobacteria> and not <OC:Gloeobacter>
Function Probably also aids protein insertion, folding and/or assembly of membrane complexes destined for the thylakoid (By similarity).
end case
Subunit Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration (By similarity).
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein (By similarity).
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein (By similarity).
end case
Similarity Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02096; 60KD_IMP; 1;
TIGRFAMs TIGR03593; YidC_nterm; 1;
TIGR03592; YidC_oxa1_C; 1;

Computed features [?]

General Transmembrane; -; 4-8; trigger=yes;

Additional information [?]

case <OC:Clostridia> or <OC:Fusobacterium>
Size range 206-465 amino acids
Size range 310-795 amino acids
end case
Related rules MF_01811 (YIDC supersedes the current rule)
Fusion Nter: <PDZ/DHR>; Cter: None
Comments N-terminal PDZ/DHR fused in RHOBA. TIGR03593 describes a large N- terminal domain of unknown function not found in all members. In most Firmicutes (MF_01811), this protein is much shorter and is probably a lipoprotein. Chlamydiae have been annotated as lipoproteins. Streptomyces seem to only have 3 transmembrane helices.