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HAMAP annotation rule: MF_01811
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General rule information

Accession MF_01811
Dates 17-NOV-2003 (Created)
8-DEC-2011 (Last updated, Version 21)
Data class Protein
Predictors HAMAP; MF_01811; [distribution of match scores in UniProtKB];[seed alignment for MF_01811]
Names YidC_type2


Propagated annotation

Identifier, protein and gene names
Identifier YIDC
Protein name
RecName: Full=Membrane protein insertase YidC;
AltName: Full=Foldase YidC;
AltName: Full=Membrane protein YidC;
AltName: Full=Membrane integrase YidC;
Flags: Precursor;
Gene name yidC
Comments
FUNCTION: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
Cross-references
Pfam PF02096; 60KD_IMP; 1;
PRINTS PR00701; 60KDINNERMP; 1;
TIGRFAMs TIGR03592; YidC_oxa1_C; 1;
PROSITE PS51257; PROKAR_LIPOPROTEIN; 1; trigger=PRU00303;
General Transmembrane; -; 4-6; trigger=Yes;
Keywords
Membrane, Cell membrane, Chaperone, Protein transport, Transmembrane, Transport.

case <Feature:PS51257>
Lipoprotein.
end case

Signal, Transmembrane helix.
Gene Ontology
GO:0005886; Cellular component: plasma membrane.


Additional information

Size range: 252-320 amino acids
Related UniRules: MF_01810 (YIDC)
Template: Q01625 (MISCA_BACSU); P54544 (MISCB_BACSU); Q8DVX3 (YIDC1_STRMU); Q8DSP8 (YIDC2_STRMU): [Recover all]
Scope: Bacteria; Firmicutes
Fusion: Nter: None; Cter: None
Duplicate: in BACAN, BACCR, BACHD, BACSU, LACLA, LACPL, LISIN, LISMO, STAES, STRA3, STRA5, STRMU, STRP3, STRP8, STRPN, STRP1, STRR6
Plasmid encoded: None
Comments: This family, which is specific to most Firmicutes, is closely related to the protein family (MF_01810) and displays a similar function. These proteins, which are often present in two copies, are however much shorter than MF_01810 proteins, and are probably lipoproteins. In the 2 organisms in which they have been studied they have overlapping but not identical functions.

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UniProtKB rule member sequences